Nothnagel syndrome
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Nothnagel syndrome is a rare midbrain stroke syndrome that involves the tectum of the midbrain, including the quadrigeminal plate 1-4. Although it can be caused by stroke, especially haemorrhages rather than infarctions, it is more commonly seen due to neoplasm 1-4. Classically, the syndrome involves the oculomotor nerve fascicles and superior cerebellar peduncle, leading to ipsilateral CN III palsy and limb ataxia respectively 1-4.
History and etymology
The syndrome was first described by Hermann Nothnagel (1841-1905), a German-Austrian physician, in 1879 5.
-<p><strong>Nothnagel syndrome</strong> is a rare <a href="/articles/midbrain-stroke-syndrome">midbrain stroke syndrome</a> that involves the tectum of the midbrain, including the <a href="/articles/quadrigeminal-plate">quadrigeminal plate</a> <sup>1-4</sup>. Although it can be caused by <a href="/articles/stroke">stroke</a>, especially haemorrhages rather than infarctions, it is more commonly seen due to neoplasm <sup>1-4</sup>. Classically, the syndrome involves the <a href="/articles/oculomotor-nerve">oculomotor nerve</a> fascicles and <a title="Superior cerebellar peduncle" href="/articles/superior-cerebellar-peduncle">superior cerebellar peduncle</a>, leading to ipsilateral <a href="/articles/oculomotor-nerve-palsy">CN III palsy</a> and limb ataxia respectively <sup>1-4</sup>. </p><h4>History and etymology</h4><p>The syndrome was first described by <strong>Hermann Nothnagel</strong> (1841-1905), a German-Austrian physician, in 1879 <sup>5</sup>.</p>- +<p><strong>Nothnagel syndrome</strong> is a rare <a href="/articles/midbrain-stroke-syndrome">midbrain stroke syndrome</a> that involves the tectum of the midbrain, including the <a href="/articles/quadrigeminal-plate">quadrigeminal plate</a> <sup>1-4</sup>. Although it can be caused by <a href="/articles/stroke">stroke</a>, especially haemorrhages rather than infarctions, it is more commonly seen due to neoplasm <sup>1-4</sup>. Classically, the syndrome involves the <a href="/articles/oculomotor-nerve">oculomotor nerve</a> fascicles and <a href="/articles/superior-cerebellar-peduncles">superior cerebellar peduncle</a>, leading to ipsilateral <a href="/articles/oculomotor-nerve-palsy">CN III palsy</a> and limb ataxia respectively <sup>1-4</sup>. </p><h4>History and etymology</h4><p>The syndrome was first described by <strong>Hermann Nothnagel</strong> (1841-1905), a German-Austrian physician, in 1879 <sup>5</sup>.</p>
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