Question 2336
{"accessible":false,"alternatives":[{"id":11540,"text":"astrocytoma grade 2"},{"id":11541,"text":"astrocytoma grade 4"},{"id":11542,"text":"glioblastoma grade 2"},{"id":11543,"text":"glioblastoma grade 4"},{"id":11544,"text":"oligodendroglioma grade 2"},{"id":11545,"text":"oligodendroglioma grade 4"}],"archived":false,"correctAlternativeId":11543,"explanation":"\u003cp\u003eGlioblastomas, in the WHO classification of tumors 2021 5\u003csup\u003eth\u003c/sup\u003e edition, are considered grade 4 astrocytic tumors that are IDH-wildtype and either have high-grade histological features (necrosis or endothelial hyperplasia) and/or\u0026nbsp;one of the following molecular changes:\u0026nbsp;\u003c/p\u003e\u003cul\u003e\n\u003cli\u003e\u003cp\u003eTERT promoter mutation\u003c/p\u003e\u003c/li\u003e\n\u003cli\u003e\u003cp\u003eEGFR gene amplification\u003c/p\u003e\u003c/li\u003e\n\u003cli\u003e\u003cp\u003ecombined gain of whole chromosome 7, loss of chromosome 10 [+7/-10]\u003c/p\u003e\u003c/li\u003e\n\u003c/ul\u003e","id":2336,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2337","nextQuestionPath":"/articles/oligodendroglioma/questions/2249","relatedArticles":[{"id":4910,"title":"Glioblastoma, IDH-wildtype","link":"/articles/glioblastoma-idh-wildtype?lang=us"},{"id":14598,"title":"Astrocytoma, IDH-mutant","link":"/articles/astrocytoma-idh-mutant-1?lang=us"}],"alsoUsedIn":[{"id":1345,"kind":"Course","title":"2022 Virtual Conference Private Use - page 1345","link":"https://radiopaedia.org/courses/2022-virtual-conference-private-use/pages/1345"},{"id":1200,"kind":"Course","title":"2022 Virtual Conference Private Use - page 1200","link":"https://radiopaedia.org/courses/2022-virtual-conference-private-use/pages/1200"},{"id":248,"kind":"LiveSchedule","title":"248","link":"https://radiopaedia.org/admin/live_schedules/248"},{"id":156,"kind":"LiveSchedule","title":"156","link":"https://radiopaedia.org/admin/live_schedules/156"},{"id":1222,"kind":"Course","title":"Diffuse Gliomas Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/diffuse-gliomas-learning-pathway/pages/1222"},{"id":1222,"kind":"Course","title":"Brain Tumours Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/brain-tumours-learning-pathway/pages/1222"},{"id":1256,"kind":"Course","title":"2022 Virtual Conference Private Use - page 1256","link":"https://radiopaedia.org/courses/2022-virtual-conference-private-use/pages/1256"},{"id":1256,"kind":"Course","title":"Neuroradiology Lectures - page 1256","link":"https://radiopaedia.org/courses/neuroradiology-lectures/pages/1256"},{"id":1256,"kind":"Course","title":"New test course - page 1256","link":"https://radiopaedia.org/courses/new-test-course/pages/1256"}],"stem":"\u003cp\u003eAn astrocytic tumor with low-grade histological features is shown to be IDH-wildtype with EGFR gene amplification. Based on the WHO 2021 5\u003csup\u003eth\u003c/sup\u003e edition, what is the best diagnosis?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/2336"}],"attemptsPercentages":[{"alternativeId":"11543","percentage":55},{"alternativeId":"11542","percentage":15},{"alternativeId":"11544","percentage":4},{"alternativeId":"11545","percentage":2},{"alternativeId":"11540","percentage":13},{"alternativeId":"11541","percentage":11}],"promptToLogin":false,"questionManager":false,"articleId":"oligodendroglioma"}