Question 2337
{"accessible":false,"alternatives":[{"id":11546,"text":"astrocytoma IDH wildtype "},{"id":11547,"text":"glioblastoma IDH wildtype "},{"id":11548,"text":"oligodendroglioma not otherwise specified (NOS)"},{"id":11549,"text":"oligodendroglioma not elsewhere classified (NEC)"}],"archived":false,"correctAlternativeId":11548,"explanation":"\u003cp\u003eWhen a tumor cannot be fully characterized using appropriate molecular markers\u0026nbsp;it requires the application of the term \u003cem\u003enot otherwise specified\u003c/em\u003e to the histological diagnosis.\u0026nbsp;\u003c/p\u003e\u003cp\u003eIn this instance, despite negative (not mutated) IDH1 R132H on immunohistochemistry, due to the age of the patient it is very likely that they have another IDH 1 or 2 mutation.\u0026nbsp;\u003c/p\u003e","id":2337,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2337","nextQuestionPath":"/articles/oligodendroglioma/questions/2336","relatedArticles":[{"id":93380,"title":"Not elsewhere classified (NEC)","link":"/articles/not-elsewhere-classified-nec?lang=us"},{"id":93379,"title":"Not otherwise specified (NOS)","link":"/articles/not-otherwise-specified-nos?lang=us"}],"alsoUsedIn":[{"id":1345,"kind":"Course","title":"2022 Virtual Conference Private Use - page 1345","link":"https://radiopaedia.org/courses/2022-virtual-conference-private-use/pages/1345"},{"id":1200,"kind":"Course","title":"2022 Virtual Conference Private Use - page 1200","link":"https://radiopaedia.org/courses/2022-virtual-conference-private-use/pages/1200"},{"id":248,"kind":"LiveSchedule","title":"248","link":"https://radiopaedia.org/admin/live_schedules/248"},{"id":156,"kind":"LiveSchedule","title":"156","link":"https://radiopaedia.org/admin/live_schedules/156"},{"id":1222,"kind":"Course","title":"Diffuse Gliomas Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/diffuse-gliomas-learning-pathway/pages/1222"},{"id":1222,"kind":"Course","title":"Brain Tumours Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/brain-tumours-learning-pathway/pages/1222"},{"id":1256,"kind":"Course","title":"2022 Virtual Conference Private Use - page 1256","link":"https://radiopaedia.org/courses/2022-virtual-conference-private-use/pages/1256"},{"id":1256,"kind":"Course","title":"Neuroradiology Lectures - page 1256","link":"https://radiopaedia.org/courses/neuroradiology-lectures/pages/1256"},{"id":1256,"kind":"Course","title":"New test course - page 1256","link":"https://radiopaedia.org/courses/new-test-course/pages/1256"}],"stem":"\u003cp\u003eA 35-year-old has a brain tumor biopsied.\u0026nbsp;It has\u0026nbsp;histological features compatible with an oligodendroglioma but is IDH-1 R132H negative on immunohistochemistry and neither next-generation sequencing nor 1p19q co-deletion status is able to be assessed due to lack of availability. What is the most appropriate diagnosis?\u0026nbsp;\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/2337"}],"attemptsPercentages":[{"alternativeId":"11548","percentage":64},{"alternativeId":"11547","percentage":9},{"alternativeId":"11549","percentage":21},{"alternativeId":"11546","percentage":6}],"promptToLogin":false,"questionManager":false,"articleId":"oligodendroglioma"}