Open ring sign
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The open ring sign is a relatively specific sign for demyelination, most commonly multiple sclerosis (MS), and is helpful in distinguishing between ring enhancinglesions. Interestingly open rignring enhancement is not seen in neuromyelitis optica(NMO). The enhancing component is thought to represent advancing front of demyelination and thus favours the white matter side of the lesion. The open part of the ring will therefore usually point towards the grey matter 3.
Often patients with such lesions undergo biopsy, where the histology can be difficult to interpret. Abundant bizarre astrocytes with frequent mitoses can suggest the diagnosis of GBM. Toxoplasmosis may also be suggested by the presence of giant cells (Creutzfeldt cells).
As such, careful assessment of imaging is essential to avoid unnecessary and misleading intervention.
-<p>The<strong> open ring sign </strong>is a relatively specific sign for <a href="/articles/demyelination">demyelination</a>, most commonly <a href="/articles/multiple-sclerosis">multiple sclerosis (MS)</a>, and is helpful in distinguishing between <a href="/articles/cerebral-ring-enhancing-lesions">ring enhancing lesions</a>. Interestingly open rign enhancement is not seen in <a href="/articles/neuromyelitis-optica">neuromyelitis optica (NMO)</a>. The enhancing component is thought to represent advancing front of demyelination and thus favours the white matter side of the lesion. The open part of the ring will therefore usually point towards the grey matter <sup>3</sup>.</p><p>Often patients with such lesions undergo biopsy, where the histology can be difficult to interpret. Abundant bizarre astrocytes with frequent mitoses can suggest the diagnosis of <a href="/articles/gbm">GBM</a>. <a href="/articles/cerebral-toxoplasmosis-2">Toxoplasmosis</a> may also be suggested by the presence of <a href="/articles/giant-cells-creutzfeldt-cells">giant cells (Creutzfeldt cells)</a></p><p>As such, careful assessment of imaging is essential to avoid unnecessary and misleading intervention. </p>- +<p>The<strong> open ring sign </strong>is a relatively specific sign for <a href="/articles/demyelination">demyelination</a>, most commonly <a href="/articles/multiple-sclerosis">multiple sclerosis (MS)</a>, and is helpful in distinguishing between <a href="/articles/cerebral-ring-enhancing-lesions">ring enhancing</a> <a href="/articles/cerebral-ring-enhancing-lesions">lesions</a>. Interestingly open ring enhancement is not seen in <a href="/articles/neuromyelitis-optica">neuromyelitis optica</a> <a href="/articles/neuromyelitis-optica">(NMO)</a>. The enhancing component is thought to represent advancing front of demyelination and thus favours the white matter side of the lesion. The open part of the ring will therefore usually point towards the grey matter <sup>3</sup>.</p><p>Often patients with such lesions undergo biopsy, where the histology can be difficult to interpret. Abundant bizarre astrocytes with frequent mitoses can suggest the diagnosis of <a href="/articles/gbm">GBM</a>. <a href="/articles/cerebral-toxoplasmosis-2">Toxoplasmosis</a> may also be suggested by the presence of <a href="/articles/giant-cells-creutzfeldt-cells">giant cells (Creutzfeldt cells)</a>.</p><p>As such, careful assessment of imaging is essential to avoid unnecessary and misleading intervention. </p>
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