Paraneoplastic cerebellar degeneration
Updates to Article Attributes
Paraneoplastic cerebellar degeneration is a type of paraneoplastic syndrome characterised by the progressive onset of cerebellar dysfunction not explained by tumoral invasion, metastasis, or treatment side effects.
Epidemiology
It is an uncommon paraneoplastic syndrome that has been reported in patients with small-cell lung cancer, ovary malignancies, breast carcinoma, and Hodgkin's lymphoma 1.
Clinical presentation
Cerebellar dysfunction may manifest as dizziness, nausea/vomiting, ataxia, diplopia, dysarthria, or dysphagia 1. A rapidly progressing gait unsteadiness is usually the key symptom that prompt for neuroimaging.
Radiographic features
Brain imaging with CT or MRI may show either normal cerebellum, particularly in initial presentation, to eventual diffuse cerebellar atrophy. Cerebellar hemispheric enlargement and cortical-meningeal enhancement have been reported 2.
Treatment and prognosis
The management is focused on the tumour treatment and supportive therapies.
-<p><strong>Paraneoplastic cerebellar degeneration</strong> is a type of <a title="Paraneoplastic syndromes" href="/articles/paraneoplastic-syndromes">paraneoplastic syndrome</a> characterised by the progressive onset of cerebellar dysfunction not explained by tumoral invasion, metastasis, or treatment side effects. </p><h4>Epidemiology</h4><p>It is an uncommon paraneoplastic syndrome that has been reported in patients with small-cell lung cancer, ovary malignancies, breast carcinoma, and Hodgkin's lymphoma <sup>1</sup>. </p><h4>Clinical presentation</h4><p>Cerebellar dysfunction may manifest as dizziness, nausea/vomiting, ataxia, diplopia, dysarthria, or dysphagia <sup>1</sup>. A rapidly progressing gait unsteadiness is usually the key symptom that prompt for neuroimaging. </p><h4>Radiographic features</h4><p>Brain imaging with CT or MRI may show either normal cerebellum, particularly in initial presentation, to eventual diffuse <a title="Diffuse cerebellar atrophy" href="/articles/diffuse-cerebellar-atrophy">cerebellar atrophy</a>. Cerebellar hemispheric enlargement and cortical-meningeal enhancement have been reported <sup>2</sup>. </p><h4>Treatment and prognosis</h4><p>The management is focused on the tumour treatment and supportive therapies. </p>- +<p><strong>Paraneoplastic cerebellar degeneration</strong> is a type of <a href="/articles/paraneoplastic-syndromes">paraneoplastic syndrome</a> characterised by the progressive onset of cerebellar dysfunction not explained by tumoral invasion, metastasis, or treatment side effects. </p><h4>Epidemiology</h4><p>It is an uncommon paraneoplastic syndrome that has been reported in patients with small-cell lung cancer, ovary malignancies, breast carcinoma, and Hodgkin's lymphoma <sup>1</sup>. </p><h4>Clinical presentation</h4><p>Cerebellar dysfunction may manifest as dizziness, nausea/vomiting, ataxia, diplopia, dysarthria, or dysphagia <sup>1</sup>. A rapidly progressing gait unsteadiness is usually the key symptom that prompt for neuroimaging. </p><h4>Radiographic features</h4><p>Brain imaging with CT or MRI may show either normal cerebellum, particularly in initial presentation, to eventual diffuse <a href="/articles/diffuse-cerebellar-atrophy">cerebellar atrophy</a>. Cerebellar hemispheric enlargement and cortical-meningeal enhancement have been reported <sup>2</sup>. </p><h4>Treatment and prognosis</h4><p>The management is focused on the tumour treatment and supportive therapies. </p>
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