POEMS syndrome
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POEMS syndrome is an acronymthe acronymic name for a rare multisystem disorderparaneoplastic disorder comprising of a minimum of three of the following features in the setting of a plasma cell dyscrasia:
- P: polyneuropathy
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O: organomegaly
- hepatomegaly, splenomegaly or lymphadenopathy
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E: endocrinopathy
- diabetes mellitus, amenorrhoea, gynaecomastia, hypothyroidism, hypoadrenalism, erectile dysfunction 4
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M: monoclonal gammopathy
- most commonly IgA lambda 4
- S: skin changes (including hyperpigmentation and skin thickening)
Associations
POEMS occurs in the setting of plasma cell dyscrasias such as osteosclerotic myeloma, or or plasmacytoma. There is an overlap with multicentric Castleman's disease 3.
-<p><strong>POEMS syndrome</strong> is an acronym for a rare multisystem disorder comprising of a minimum of three of the following features in the setting of a <a href="/articles/plasma-cell-dyscrasia">plasma cell dyscrasia</a>:</p><ul>- +<p><strong>POEMS syndrome</strong> is the acronymic name for a rare multisystem <a title="Paraneoplastic syndromes" href="/articles/paraneoplastic-syndromes">paraneoplastic</a> disorder comprising of a minimum of three of the following features in the setting of a <a href="/articles/plasma-cell-dyscrasia">plasma cell dyscrasia</a>:</p><ul>
-<strong>O:</strong> organomegaly</li>- +<strong>O:</strong> organomegaly<ul><li>hepatomegaly, <a title="Splenomegaly" href="/articles/splenomegaly">splenomegaly</a> or lymphadenopathy</li></ul>
- +</li>
-<strong>E:</strong> endocrinopathy</li>- +<strong>E:</strong> endocrinopathy<ul><li>diabetes mellitus, amenorrhoea, <a title="Gynaecomastia" href="/articles/gynaecomastia">gynaecomastia</a>, hypothyroidism, hypoadrenalism, erectile dysfunction <sup>4</sup>
- +</li></ul>
- +</li>
-<strong>M:</strong> monoclonal gammopathy</li>- +<strong>M:</strong> monoclonal gammopathy<ul><li>most commonly IgA lambda <sup>4</sup>
- +</li></ul>
- +</li>
-</ul><h5>Associations</h5><p><strong>POEMS</strong> occurs in the setting of plasma cell dyscrasias such as <a title="Osteosclerotic myeloma" href="/articles/osteosclerosing-myeloma">osteosclerotic myeloma</a>, or <a href="/articles/plasmacytoma">plasmacytoma</a>. There is an overlap with multicentric <a href="/articles/castleman-disease">Castleman's disease</a> <sup>3</sup>.</p>- +</ul><h5>Associations</h5><p><strong>POEMS</strong> occurs in the setting of plasma cell dyscrasias such as <a href="/articles/osteosclerosing-myeloma">osteosclerotic myeloma</a> or <a href="/articles/plasmacytoma">plasmacytoma</a>. There is an overlap with multicentric <a href="/articles/castleman-disease">Castleman disease</a> <sup>3</sup>.</p>
References changed:
Systems changed:
- Oncology
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