Radiation and chemotherapy induced cystitis
Updates to Article Attributes
Both radiation and chemotherapy can result in severe haemorrhagic cystitis, the appearances of which vary with time from the therapy. It can be divided into acute and chronic.
Pathology
Acute
In the acute phase of radiation and chemotherapy cystitis, there is haemorrhagic cystitis secondary to denudation of the urothelium.
The most severe radiation injuries cause bladder necrosis, incontinence, and fistula formation.
At histologic analysis, there is cellular atypia, with mild to moderate nuclear pleomorphism. The epithelial proliferation may be so marked as to be confused with invasive cancer in the lamina propria.
Chronic
Beyond 1 year, chronic radiation effects result from an obliterative endarteritis in the lamina propria, followed by ischemicischaemic changes and interstitial fibrosis.
Radiographic features
As expected, the imaging appearances also vary depending on whether the changes are acute or chronic.
Acute
AtGeneral imaging, there is demonstrates an abnormal bladder wall with focal or diffuse irregular thickening, spasticity, and decreased distensibility.
Hypervascularity in the wall and bleeding vessels result in an intraluminal clot, visible at US or CT.
MR imaging may show inflammation and edemaoedema as high signal intensity with T2-weighted sequences and can enable the bladder wall to be distinguished from the clot.
Chronic
At imaging, a small fibrosed bladder with a thick wall and resultant hydronephrosis are seen.
Calcification is only rarely seen.
Other evidence of previous irradiation includes fatty replacement of the pelvic musculature and widening of the presacral space
Fistulas may occur and pneumaturia and fecaluria are highly suggestive of a fistula.
-<p>Both <strong>radiation and chemotherapy</strong> can result in severe <a href="/articles/haemorrhagic-cystitis">haemorrhagic cystitis</a>, the appearances of which vary with time from the therapy. It can be divided into acute and chronic. </p><h4>Acute</h4><p>In the acute phase of radiation and chemotherapy cystitis, there is haemorrhagic cystitis secondary to denudation of the urothelium.</p><p>The most severe radiation injuries cause bladder necrosis, incontinence, and fistula formation.</p><p>At histologic analysis, there is cellular atypia, with mild to moderate nuclear pleomorphism. The epithelial proliferation may be so marked as to be confused with invasive cancer in the lamina propria.</p><h4>Chronic</h4><p>Beyond 1 year, chronic radiation effects result from an obliterative endarteritis in the lamina propria, followed by ischemic changes and interstitial fibrosis.</p><h4>Radiographic features</h4><p>As expected the imaging appearances also vary depending on whether the changes are acute or chronic. </p><h5>Acute</h5><p>At imaging, there is an abnormal bladder wall with focal or diffuse irregular thickening, spasticity, and decreased distensibility.</p><p>Hypervascularity in the wall and bleeding vessels result in an intraluminal clot, visible at US or CT.</p><p>MR imaging may show inflammation and edema as high signal intensity with T2-weighted sequences and can enable the bladder wall to be distinguished from the clot.</p><h5>Chronic</h5><p>At imaging, a small fibrosed bladder with a thick wall and resultant hydronephrosis are seen.</p><p>Calcification is only rarely seen.</p><p>Other evidence of previous irradiation includes fatty replacement of the pelvic musculature and widening of the presacral space</p><p>Fistulas may occur and pneumaturia and fecaluria are highly suggestive of a fistula.</p>- +<p>Both <strong>radiation and chemotherapy</strong> can result in severe <a href="/articles/haemorrhagic-cystitis">haemorrhagic cystitis</a>, the appearances of which vary with time from the therapy. It can be divided into acute and chronic. </p><h4>Pathology</h4><h5>Acute</h5><p>In the acute phase of radiation and chemotherapy cystitis, there is haemorrhagic cystitis secondary to denudation of the urothelium.</p><p>The most severe radiation injuries cause bladder necrosis, incontinence, and fistula formation.</p><p>At histologic analysis, there is cellular atypia, with mild to moderate nuclear pleomorphism. The epithelial proliferation may be so marked as to be confused with invasive cancer in the lamina propria.</p><h5>Chronic</h5><p>Beyond 1 year, chronic radiation effects result from an obliterative endarteritis in the lamina propria, followed by ischaemic changes and interstitial fibrosis.</p><h4>Radiographic features</h4><p>As expected, the imaging appearances also vary depending on whether the changes are acute or chronic. </p><h5>Acute</h5><p>General imaging demonstrates an abnormal bladder wall with focal or diffuse irregular <a href="/articles/bladder-wall-thickening-differential" title="Bladder wall thickening (differential)">thickening</a>, spasticity, and decreased distensibility.</p><p>Hypervascularity in the wall and bleeding vessels result in an intraluminal clot, visible at US or CT.</p><p>MR imaging may show inflammation and oedema as high signal intensity with T2-weighted sequences and can enable the bladder wall to be distinguished from the clot.</p><h5>Chronic</h5><p>At imaging, a small fibrosed bladder with a thick wall and resultant <a href="/articles/hydronephrosis" title="Hydronephrosis">hydronephrosis</a> are seen.</p><p><a href="/articles/urinary-bladder-wall-or-lumen-calcification-differential" title="Bladder wall calcification (differential diagnosis)">Calcification</a> is only rarely seen.</p><p>Other evidence of previous irradiation includes <a href="/articles/intramural-fat-of-the-urinary-bladder" title="Intramural fat of the urinary bladder">fatty replacement of the pelvic musculature</a> and widening of the presacral space</p><p><a href="/articles/fistula" title="Fistula">Fistulas</a> may occur and pneumaturia and fecaluria are highly suggestive of a fistula.</p>
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