Stewart-Treves syndrome
Updates to Article Attributes
Stewart-Treves syndrome refers to an angiosarcoma seen in the setting of lymphoedema 1.
It was classically attributed to lymphoedemas induced by radical mastectomy to treat breast cancer. Nowadays, we know that it can arise in chronically lymphoedematous regions of any cause 2.
The incidence is unknown, but studies have shown that it occurred inat a rate of between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy 5,6.
Pathology
Etiology
It can arise from any cause of chronic lymphoedema 3,4:
- mastectomy induced lymphoedema
- Milroy disease
- congenital lymphoedema
- traumatic lymphoedema
- filarial lymphoedema
- elephantiasis nostras verrucosa
- idiopathic lymphoedema
Pathophysiology
Chronic lymphoedema seems to induce a degree of local immunodeficiency that leads to oncogenesis 7.
Treatment and prognosis
The prognosis is very poor because angiosarcomas are very aggressive tumors that frequently recur locally and often metastasize early.
-<p><strong>Stewart-Treves syndrome</strong> refers to an <a href="/articles/angiosarcoma">angiosarcoma</a> seen in the setting of <a href="/articles/lymphoedema">lymphoedema</a> <sup>1</sup>.</p><p>It was classically attributed to lymphoedemas induced by <a href="/articles/radical-mastectomy">radical mastectomy</a> to treat <a href="/articles/breast-neoplasms">breast cancer</a>. Nowadays, we know that it can arise in chronically lymphoedematous regions of any cause <sup>2</sup>. </p><p>The incidence is unknown, but studies have shown that it occurred in a rate between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy <sup>5,6</sup>.</p><h4>Pathology</h4><h5>Etiology</h5><p>It can arise from any cause of chronic lymphoedema <sup>3,4</sup>:</p><ul>- +<p><strong>Stewart-Treves syndrome</strong> refers to an <a href="/articles/angiosarcoma">angiosarcoma</a> seen in the setting of <a href="/articles/lymphoedema">lymphoedema</a> <sup>1</sup>.</p><p>It was classically attributed to lymphoedemas induced by <a href="/articles/radical-mastectomy">radical mastectomy</a> to treat <a href="/articles/breast-neoplasms">breast cancer</a>. Nowadays, we know that it can arise in chronically lymphoedematous regions of any cause <sup>2</sup>. </p><p>The incidence is unknown, but studies have shown that it occurred at a rate of between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy <sup>5,6</sup>.</p><h4>Pathology</h4><h5>Etiology</h5><p>It can arise from any cause of chronic lymphoedema <sup>3,4</sup>:</p><ul>
References changed:
- 5. Scherger A. Postoperative lymphedema: etiologic and diagnostic factors. (1962) The Medical clinics of North America. 46: 1045-50. <a href="https://www.ncbi.nlm.nih.gov/pubmed/14498466">Pubmed</a> <span class="ref_v4"></span>
- 5. SCHIRGER A. Postoperative lymphedema: etiologic and diagnostic factors. (1962) The Medical clinics of North America. 46: 1045-50. <a href="https://www.ncbi.nlm.nih.gov/pubmed/14498466">Pubmed</a> <span class="ref_v4"></span>