Stupp protocol
Disclosures
- updated 4 Apr 2022:
- Radiopaedia Australia Pty Ltd, Founder and CEO (ongoing)
- Biogen Australia Pty Ltd, Investigator-Initiated Research Grant for CAD software development in multiple sclerosis (past)
Updates to Article Attributes
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was changed:
The Stupp protocol has become the standard of care for the treatment of glioblastoma (GBM) since since its publication in 2005 and has leadled to significant survival improvements 1. It consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent.
Protocol
According to the original study, the Stupp protocol comprises:
- radiotherapy
- total 60 Gy
- 2 Gy per daily fraction (Monday to Friday) over 6 weeks
-
temozolomide
-
during radiotherapy: 75 mg per square
metermetre of body-surface area per day, 7 days per week - post-radiotherapy (adjuvant): six cycles consisting of 150-200 mg per square
metermetre for 5 days during each 28-day cycle
-
during radiotherapy: 75 mg per square
Prognosis
This therapy resulted in a significant survival improvement at 2 years:
- 26.5% 2-year-survival with Stupp protocol
- 10.4% 2-year-survival with radiotherapy alone
A substantial minority of patients can demonstrate changes of pseudoprogression on follow up imaging.
History and etymology
The Stupp protocol is named after Roger Stupp the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich 1.
-<p>The <strong>Stupp protocol</strong> has become standard of care for the treatment of <a href="/articles/glioblastoma">glioblastoma (GBM)</a> since its publication in 2005 and has lead to significant survival improvements <sup>1</sup>. It consists of radiotherapy and concomitant chemotherapy with <a href="/articles/temozolomide">temozolomide</a>, an alkylating agent.</p><p>According to the original study the Stupp protocol comprises: </p><ul>- +<p>The <strong>Stupp protocol</strong> has become the standard of care for the treatment of <a href="/articles/glioblastoma-idh-wildtype">glioblastoma</a> since its publication in 2005 and has led to significant survival improvements <sup>1</sup>. It consists of radiotherapy and concomitant chemotherapy with <a href="/articles/temozolomide">temozolomide</a>, an alkylating agent.</p><h4>Protocol</h4><p>According to the original study, the Stupp protocol comprises: </p><ul>
-<a href="/articles/temozolomide"></a>during radiotherapy: 75 mg per square meter of body-surface area per day, 7 days per week</li>-<li>post-radiotherapy (adjuvant): six cycles consisting of 150-200 mg per square meter for 5 days during each 28-day cycle</li>- +<a href="/articles/temozolomide"></a>during radiotherapy: 75 mg per square metre of body-surface area per day, 7 days per week</li>
- +<li>post-radiotherapy (adjuvant): six cycles consisting of 150-200 mg per square metre for 5 days during each 28-day cycle</li>
-</ul><p>This therapy resulted in a significant survival improvement at 2 years: </p><ul>- +</ul><h4>Prognosis</h4><p>This therapy resulted in a significant survival improvement at 2 years: </p><ul>
-</ul><h4>History and etymology</h4><p>The Stupp protocol is named after <strong>Roger Stupp</strong> the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich <sup>1</sup>. </p>- +</ul><p>A substantial minority of patients can demonstrate changes of <a title="Tumour pseudoprogression (brain tumors)" href="/articles/tumour-pseudoprogression-brain-tumors">pseudoprogression</a> on follow up imaging. </p><h4>History and etymology</h4><p>The Stupp protocol is named after <strong>Roger Stupp</strong> the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich <sup>1</sup>. </p>
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