Stupp protocol
Updates to Article Attributes
The Stupp protocol has become the standard of care for the treatment of high-grade astrocytoma and glioblastoma since since its publication in 2005 and has led to significant survival improvements 1. It consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent.
Protocol
According to the original study, the Stupp protocol comprises:
-
radiotherapy
total 60 Gy
2 Gy per daily fraction (Monday to Friday) over 6 weeks
-
during radiotherapy:
7575 mg per square metre of body-surface area per day, 7 days per weekpost-radiotherapy (adjuvant):
66 cycles consisting of 150-200 mg per square metre for 5 days during each 28-day cycle
Prognosis
This therapy resulted in a significant survival improvement at 2 years:
26.5% 2-year-survival with Stupp protocol
10.4%
22-year-survival with radiotherapy alone
A substantial minority of patients can demonstrate changes of pseudoprogression on follow-up imaging.
History and etymology
The Stupp protocol is named after Roger Stupp the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich 1.
-<p>The <strong>Stupp protocol</strong> has become the standard of care for the treatment of <a href="/articles/glioblastoma-idh-wildtype">glioblastoma</a> since its publication in 2005 and has led to significant survival improvements <sup>1</sup>. It consists of radiotherapy and concomitant chemotherapy with <a href="/articles/temozolomide">temozolomide</a>, an alkylating agent.</p><h4>Protocol</h4><p>According to the original study, the Stupp protocol comprises: </p><ul>- +<p>The <strong>Stupp protocol</strong> has become the standard of care for the treatment of high-grade astrocytoma and <a href="/articles/glioblastoma-idh-wildtype">glioblastoma</a> since its publication in 2005 and has led to significant survival improvements <sup>1</sup>. It consists of radiotherapy and concomitant chemotherapy with <a href="/articles/temozolomide">temozolomide</a>, an alkylating agent.</p><h4>Protocol</h4><p>According to the original study, the Stupp protocol comprises: </p><ul>
-<li><p><a href="/articles/temozolomide"></a>during radiotherapy: 75 mg per square metre of body-surface area per day, 7 days per week</p></li>-<li><p>post-radiotherapy (adjuvant): 6 cycles consisting of 150-200 mg per square metre for 5 days during each 28-day cycle</p></li>- +<li><p><a href="/articles/temozolomide"></a>during radiotherapy: 75 mg per square metre of body-surface area per day, 7 days per week</p></li>
- +<li><p>post-radiotherapy (adjuvant): 6 cycles consisting of 150-200 mg per square metre for 5 days during each 28-day cycle</p></li>
-</ul><h4>Prognosis</h4><p>This therapy resulted in a significant survival improvement at 2 years: </p><ul>- +</ul><h4>Prognosis</h4><p>This therapy resulted in a significant survival improvement at 2 years: </p><ul>
-<li><p>10.4% 2-year-survival with radiotherapy alone</p></li>-</ul><p>A substantial minority of patients can demonstrate changes of <a href="/articles/tumour-pseudoprogression-brain-tumors" title="Tumour pseudoprogression (brain tumors)">pseudoprogression</a> on follow-up imaging. </p><h4>History and etymology</h4><p>The Stupp protocol is named after <strong>Roger Stupp</strong> the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich <sup>1</sup>. </p>- +<li><p>10.4% 2-year-survival with radiotherapy alone</p></li>
- +</ul><p>A substantial minority of patients can demonstrate changes of <a href="/articles/tumour-pseudoprogression-brain-tumors" title="Tumour pseudoprogression (brain tumors)">pseudoprogression</a> on follow-up imaging. </p><h4>History and etymology</h4><p>The Stupp protocol is named after <strong>Roger Stupp</strong> the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich <sup>1</sup>. </p>
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