Subarachnoid lymphatic-like membrane
Updates to Article Attributes
The subarachnoid lymphatic-like membrane (SLYM) is a recently discovered fourth meningeal layer which compartmentalizes the subarachnoid space into two functional compartments.
Gross anatomy
The subarachnoid lymphatic-like membrane is only a few cells thin layer, which renders it invisible using current clinical neuroimaging techniques. The SLYM forms a barrier through which cerebrospinal fluid solutes over 3 kDa cannot pass, thus it divides the subarachnoid space into two distinct compartments 1.
Clinical importance
The membrane is morphologically similar to peripheral mesothelial membranes and it is rich in myeloid cells, thus it likely has a significant role in the response to inflammation. It has also been proposed that physical injury to this thin tissue layer could alter CSF flow, and could explain the prolonged neuroinflammation and the increased risk of developing e.g. Alzheimer's disease after closed head injury 1.
-<p>The <strong>subarachnoid lymphatic-like membrane</strong> (SLYM) is a recently discovered fourth <a href="/articles/meninges" title="Meninges">meningeal</a> layer which compartmentalizes the <a href="/articles/subarachnoid-space" title="Subarachnoid space">subarachnoid space</a> into two functional compartments. </p><h4>-<br>Gross anatomy</h4><p>The subarachnoid lymphatic-like membrane is only a few cells thin layer, which renders it invisible using current clinical neuroimaging techniques. The SLYM forms a barrier through which <a href="/articles/cerebrospinal-fluid-1" title="Cerebrospinal fluid">cerebrospinal fluid</a> solutes over 3 kDa cannot pass, thus it divides the subarachnoid space into two distinct compartments <sup>1</sup>. </p><p></p><h4>Clinical importance</h4><p><br>The membrane is morphologically similar to peripheral mesothelial membranes and it is rich in myeloid cells, thus it likely has a significant role in the response to inflammation. It has also been proposed that physical injury to this thin tissue layer could alter CSF flow, and could explain the prolonged neuroinflammation and the increased risk of developing e.g. <a href="/articles/alzheimer-disease-1" title="Alzheimer's disease">Alzheimer's disease</a> after closed head injury <sup>1</sup>. </p>- +<p>The <strong>subarachnoid lymphatic-like membrane</strong> (SLYM) is a recently discovered fourth <a href="/articles/meninges" title="Meninges">meningeal</a> layer which compartmentalizes the <a href="/articles/subarachnoid-space" title="Subarachnoid space">subarachnoid space</a> into two functional compartments.</p><h4>Gross anatomy</h4><p>The subarachnoid lymphatic-like membrane is only a few cells thin layer, which renders it invisible using current clinical neuroimaging techniques. The SLYM forms a barrier through which <a href="/articles/cerebrospinal-fluid-1" title="Cerebrospinal fluid">cerebrospinal fluid</a> solutes over 3 kDa cannot pass, thus it divides the subarachnoid space into two distinct compartments <sup>1</sup>. </p><h4>Clinical importance</h4><p>The membrane is morphologically similar to peripheral mesothelial membranes and it is rich in myeloid cells, thus it likely has a significant role in the response to inflammation. It has also been proposed that physical injury to this thin tissue layer could alter CSF flow, and could explain the prolonged neuroinflammation and the increased risk of developing e.g. <a href="/articles/alzheimer-disease-1" title="Alzheimer's disease">Alzheimer's disease</a> after closed head injury <sup>1</sup>. </p>
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