Subarachnoid lymphatic-like membrane
Updates to Article Attributes
Thesubarachnoid lymphatic-like membrane (SLYM) is a recently discovered fourth meningeal layer which compartmentalizescompartmentalises the subarachnoid space into two functional compartments.
Gross anatomy
The subarachnoid subarachnoid lymphatic-like membrane is only a few cells thin layer, which renders it invisible using current clinical neuroimaging techniques. The SLYM forms a barrier through which cerebrospinal fluid solutes over 3 kDa cannot pass, thus it divides the subarachnoid subarachnoid space into two distinct compartments 1.
Clinical importance
The membrane is morphologically similar to to peripheral mesothelial membranes and it is rich in myeloid cells, thus it likely has a significant role in the response to to inflammation. It has also been been proposed that physical injury to this thin tissue tissue layer could alter CSF flow, and could explain the prolonged neuroinflammation and the increased risk of developing conditions such as Alzheimer disease after closed head injury 1.
-<p>The <strong>subarachnoid lymphatic-like membrane</strong> (SLYM) is a recently discovered fourth <a href="/articles/meninges" title="Meninges">meningeal</a> layer which compartmentalizes the <a href="/articles/subarachnoid-space" title="Subarachnoid space">subarachnoid space</a> into two functional compartments.</p><h4>Gross anatomy</h4><p>The subarachnoid lymphatic-like membrane is only a few cells thin layer, which renders it invisible using current clinical neuroimaging techniques. The SLYM forms a barrier through which <a href="/articles/cerebrospinal-fluid-1" title="Cerebrospinal fluid">cerebrospinal fluid</a> solutes over 3 kDa cannot pass, thus it divides the subarachnoid space into two distinct compartments <sup>1</sup>. </p><h4>Clinical importance</h4><p>The membrane is morphologically similar to peripheral mesothelial membranes and it is rich in myeloid cells, thus it likely has a significant role in the response to inflammation. It has also been proposed that physical injury to this thin tissue layer could alter CSF flow, and could explain the prolonged neuroinflammation and the increased risk of developing conditions such as <a href="/articles/alzheimer-disease-1" title="Alzheimer's disease">Alzheimer disease</a> after closed head injury <sup>1</sup>. </p>- +<p>The <strong>subarachnoid lymphatic-like membrane</strong> (SLYM) is a fourth <a href="/articles/meninges" title="Meninges">meningeal</a> layer which compartmentalises the <a href="/articles/subarachnoid-space" title="Subarachnoid space">subarachnoid space</a> into two functional compartments.</p><h4>Gross anatomy</h4><p>The subarachnoid lymphatic-like membrane is only a few cells thin layer, which renders it invisible using current clinical neuroimaging techniques. The SLYM forms a barrier through which <a href="/articles/cerebrospinal-fluid-1" title="Cerebrospinal fluid">cerebrospinal fluid</a> solutes over 3 kDa cannot pass, thus it divides the subarachnoid space into two distinct compartments <sup>1</sup>. </p><h4>Clinical importance</h4><p>The membrane is morphologically similar to peripheral mesothelial membranes and it is rich in myeloid cells, thus it likely has a significant role in the response to inflammation. It has also been proposed that physical injury to this thin tissue layer could alter CSF flow, and could explain the prolonged neuroinflammation and the increased risk of developing conditions such as <a href="/articles/alzheimer-disease-1" title="Alzheimer's disease">Alzheimer disease</a> after closed head injury <sup>1</sup>.</p>
Unable to process the form. Check for errors and try again.