The thymic tumor staging using the TNM staging system only applies to the epithelial types including thymoma, thymic carcinoma, and neuroendocrine tumors of the thymus. It does not apply to thymic sarcoma, primary thymic lymphoma or other rare tumors.
This staging system is based upon recommendations from the International Association for the Study of Lung Cancer (IASLC) Staging Project and the International Thymic Malignancies Interest Group (ITMIG)
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Primary tumor (T)
Tx: primary tumor cannot be assessed
T0: no evidence of a primary tumor
-
T1: tumor encapsulated or extending into the mediastinal fat, may involve the mediastinal pleura.
T1a: no mediastinal pleural involvement
T1b: direct invasion of the mediastinal pleura
T2: tumor with direct involvement of the pericardium (partial or full thickness)
T3: tumor with direct invasion into any of the following; lung, brachiocephalic vein, superior vena cava, phrenic nerve, chest wall, or extra-pericardial pulmonary artery or vein.
T4: tumor with direct invasion into any of the following; aorta (ascending, arch or descending), arch vessels, intrapericardial pulmonary artery, myocardium, trachea, or esophagus
Regional lymph node (N)
The regional lymph nodes are the anterior (perithymic) lymph nodes, the deep intrathoracic lymph nodes and the cervical lymph nodes.
Nx: regional lymph nodes cannot be assessed
N0: no regional lymph node metastasis
N1: metastasis in anterior (perithymic) lymph nodes
N2: metastasis in deep intrathoracic or cervical lymph nodes
Distant metasisis (M)
M0: no pleural, pericardial or distant metastasis
-
M1: distant metastasis present
M1a: separate pleural or pericardial nodule(s)
M1b: distant metastasis beyond the pleura or pericardium
Stage groups
stage I: TNM equivalent: T1, N0, M0
stage II: TNM equivalent: T2b, N0, M0
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stage IIIa
TNM equivalent: T3, N0, M0
T4, N0, M0
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stage IIIb
TNM equivalent: T4, N0, M0
-
stage IVa
TNM equivalent: any T, N1, M0
any T, N0/N1, M1a
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stage IVb
TNM equivalent: any T, N2, M0 / M1a
any T, any N, M1b