Thyroid-associated orbitopathy
Updates to Article Attributes
Thyroid-associated orbitopathy (TAO) is the most common cause of proptosis in adults and is most frequently associated with Graves disease.
On imaging, it is characterised by extra-ocular muscles bellies enlargement (frequently: inferior rectus > medial rectus > superior rectus) sparing their tendinous insertions, usually bilateral and symmetrical.
Epidemiology
The demographics of thyroid associated orbitopathy reflects that of patients with thyroid disease and is, therefore, more frequently seen in women. Although Graves disease is the most common cause, Hashimoto thyroiditis has also been implicated. It may precede, occur concurrently with, or after the onset of abnormal thyroid function.
Clinical presentation
- lid retraction
- proptosis, with resultant chemosis and corneal dryness and ulceration
- optic nerve compression potentially leading to blindness
- diplopia 1
Pathology
Thyroid associated orbitopathy is characterised by enlargement of the extra-ocular muscles (EOMs) as well as the increase in the orbital fat volume 1. While the exact mechanism is unknown, antibodies to thyroid stimulating hormone (TSH) appear to cross react with antigens in the orbit resulting in infiltration by activated T lymphocytes 3, with subsequent release of inflammatory mediators.
The muscles are infiltrated with inflammatory cells (lymphocytes, macrophages, plasma cells and eosinophils), and increased mucopolysccaride deposition. In long standing cases, increased collagen deposition leads to fibrosis 1.
The extra-ocular muscles are involved in a predictable fashion as remembered by the I'M SLOW mnemonic. Involvement of the rectus muscles in decreasing order of frequency:
- inferior
- medial
- superior
- lateral
- obliques
Increase in orbital fat volume is a result of venous congestion from the compression of the superior ophthalmic vein by enlarged muscles and/or intrinsic adipose inflammation.
Radiographic features
CT
CT is the most commonly used modality, due to its widespread availability and rapid image acquisition. Contrast, although ideal, is not necessary as the natural contrast between orbital fat and muscle allows for adequate delineation of the orbital contentcontents.
CT findings include:
- exophthalmos
- can be measured by drawing a line between the anterior tips of the zygomatic bones and measuring the distance between the line and the posterior part of the eyeball. The normal distance is more than 10±1.7mm 6 and a smaller distance indicates exopthalmus
- extraocular muscle enlargement and fatty attenuation
- muscle involvement can be remembered by the mnemonic I'M SLOW
- bilateral (76-90%) and symmetric (70%) involvement is typical
- anterior tendon is typically spared (although it can be involved in acute cases) with the swelling largely confined to the muscle belly
- this appearance if often referred to as 'coke bottle' in nature (coca-cola bottle sign), given its resemblance to the classic Coca-ColaTM bottle
- enlargement of the muscle belly is usually accompanied by reduced attenuation representing fatty infiltration 7
- size of the muscles correlates with both the severity of disease and the risk of optic nerve compression 7
- increase in retro-ocular orbital fat
When muscle involvement is pronounced the optic nerve may be crowded at the orbital apex, leading to optic nerve dysfunction 1. Variation in the shape of the orbit, especially the angle formed by the medial and lateral walls at the apex, changes the likelihood of optic nerve compression 2.
Other rarer signs include 7:
- enlargement of the lacrimal glands (lymphocytic infiltration)
- chemosis
- anterior displacement of the orbital septum
MRI
MRI may also be used in evaluation due to its multiplanar and the inherent contrast capabilities. Use of MR prevents ionising radiation to orbits, which is associated with radiation-induced cataracts. The imaging findings are similar as described above for CT in terms of location and ocular muscles involved.
-
T1:
isosinaliso-signal to the other facial muscles, or fatty infiltration - T2: increased signal intensity may be seen due the inflammatory process
- T1 C+ (Gd): enhancement may be present
Treatment and prognosis
Although in many instances the disease is self-limiting, spontaneously improving within 2-5 years 3 often discomfort, cosmetic issues, the risk of corneal ulceration and optic nerve compression requires treatment. Options include:
- medical: supportive, steroids
- radiotherapy 3
- surgical decompression
Differential diagnosis
General imaging differential considerations include:
-</ul><p>Increase in orbital fat volume is a result of venous congestion from the compression of the <a href="/articles/superior-ophthalmic-vein">superior ophthalmic vein</a> by enlarged muscles and/or intrinsic adipose inflammation.</p><h4>Radiographic features</h4><h5>CT</h5><p>CT is the most commonly used modality, due to its widespread availability and rapid image acquisition. Contrast, although ideal, is not necessary as the natural contrast between orbital fat and muscle allows for adequate delineation of the orbital content.</p><p>CT findings include:</p><ul>- +</ul><p>Increase in orbital fat volume is a result of venous congestion from the compression of the <a href="/articles/superior-ophthalmic-vein">superior ophthalmic vein</a> by enlarged muscles and/or intrinsic adipose inflammation.</p><h4>Radiographic features</h4><h5>CT</h5><p>CT is the most commonly used modality, due to its widespread availability and rapid image acquisition. Contrast, although ideal, is not necessary as the natural contrast between orbital fat and muscle allows for adequate delineation of the orbital contents.</p><p>CT findings include:</p><ul>
-</ul><h5>MRI</h5><p>MRI may also be used in evaluation due to its multiplanar and the inherent contrast capabilities. Use of MR prevents ionising radiation to orbits. The imaging findings are similar as described above for CT in terms of location and ocular muscles involved.</p><ul>- +</ul><h5>MRI</h5><p>MRI may also be used in evaluation due to its multiplanar and the inherent contrast capabilities. Use of MR prevents ionising radiation to orbits, which is associated with radiation-induced cataracts. The imaging findings are similar as described above for CT in terms of location and ocular muscles involved.</p><ul>
-<strong>T1:</strong> isosinal to the other facial muscles</li>- +<strong>T1:</strong> iso-signal to the other facial muscles, or fatty infiltration</li>
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