Thyroseq

Last revised by Andrew Murphy on 23 Mar 2023

Citation, DOI, disclosures and article data

Citation:

Morgan M, Knipe H, Bell D, Thyroseq. Reference article, Radiopaedia.org (Accessed on 24 Apr 2024) https://doi.org/10.53347/rID-56785

DOI:

https://doi.org/10.53347/rID-56785

Permalink:

https://radiopaedia.org/articles/56785

rID:

56785

Article created:

21 Nov 2017, Matt A. Morgan ◉

Disclosures:

At the time the article was created Matt A. Morgan had no recorded disclosures.

View Matt A. Morgan's current disclosures

Last revised:

23 Mar 2023, Andrew Murphy ◉

Disclosures:

At the time the article was last revised Andrew Murphy had no financial relationships to ineligible companies to disclose.

View Andrew Murphy's current disclosures

Revisions:

6 times, by 3 contributors - see full revision history and disclosures

Systems:

Head & Neck

Sections:

Pathology

Tags:

stub, thyroid nodule, fna, thyroid

Thyroseq^®is an expanded gene classifier test designed for further evaluation of indeterminate thyroid nodules on fine needle aspiration (FNA). In particular, it is designed to further evaluate nodules that show atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) on cytology. It can also be used to risk-stratify nodules that show follicular neoplasm cytology ².

The test is a multigene next-generation assay that evaluates for multiple mutations in thyroid cancer. Early results suggest that it offers increased sensitivity and specificity over standard gene expression classifier/AFIRMA testing for detection of cancer in these indeterminate nodules. The most recent iteration of the test is version 3 (as of late 2019). It uses DNA, mRNA, and miRNA markers for evaluation.