Tumor pseudoresponse
Updates to Article Attributes
Tumour pseudoresponse, also known as just as Pseudoresponse, refers to a false image impression of a tumour response to a specific treatment when actually the lesion remains stable or has progressed. The term is largely used in brain tumours imaging follow-ups, especially for high grade gliomas (e.g. GBM) in which a rapid decrease in contrast enhancement could be observed in a short period of time after administration of antiangiogenic agents (e.g, bevacizumab and cediranib), without any significative change in T2/FLAIR lesion pattern1-3.
Despite the fact that new advanced MRI sequences have been helping in differentiating pseudoresponse from a trues response, imaging follow-up is still the best way to achieve this answer 1. To assess this cases comparison must be done with previous studies and treatment information must be provide to the radiologist.
-<p><strong>Tumour pseudoresponse</strong>, also known as just <strong>Pseudoresponse<em>,</em></strong> refers to a false image impression of a tumour response to a specific treatment when actually the lesion remains stable or has progressed. The term is largely used in brain tumours imaging follow-ups, especially for high grade gliomas (e.g. GBM) in which a rapid decrease in contrast enhancement could be observed in a short period of time after administration of antiangiogenic agents (e.g, bevacizumab and cediranib), without any significative change in T2/FLAIR lesion pattern. </p><p>Despite the fact that new advanced MRI sequences have been helping in differentiating pseudoresponse from a trues response, imaging follow-up is still the best way to achieve this answer <sup>1</sup>. To assess this cases comparison must be done with previous studies and treatment information must be provide to the radiologist. </p><p><!--EndFragment--></p>- +<p><strong>Tumour pseudoresponse</strong>, also known just as <strong>Pseudoresponse</strong><em>,</em> refers to a false image impression of a tumour response to a specific treatment when actually the lesion remains stable or has progressed. The term is largely used in brain tumours imaging follow-ups, especially for high grade gliomas (e.g. <a href="/articles/glioblastoma">GBM</a>) in which a rapid decrease in contrast enhancement could be observed in a short period of time after administration of antiangiogenic agents (e.g, bevacizumab and cediranib), without any significative change in T2/FLAIR lesion pattern <sup>1-3</sup>. </p><p>Despite the fact that new advanced MRI sequences have been helping in differentiating pseudoresponse from a trues response, imaging follow-up is still the best way to achieve this answer <sup>1</sup>. To assess this cases comparison must be done with previous studies and treatment information must be provide to the radiologist. </p><p> </p><p><!--EndFragment--></p>
References changed:
- 1. Hygino da Cruz L, Rodriguez I, Domingues R, Gasparetto E, Sorensen A. Pseudoprogression and Pseudoresponse: Imaging Challenges in the Assessment of Posttreatment Glioma. AJNR Am J Neuroradiol. 2011;32(11):1978-85. <a href="https://doi.org/10.3174/ajnr.A2397">doi:10.3174/ajnr.A2397</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/21393407">Pubmed</a>
- 2. Brandsma D & van den Bent M. Pseudoprogression and Pseudoresponse in the Treatment of Gliomas. Curr Opin Neurol. 2009;22(6):633-8. <a href="https://doi.org/10.1097/WCO.0b013e328332363e">doi:10.1097/WCO.0b013e328332363e</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/19770760">Pubmed</a>
- 3. Clarke J & Chang S. Pseudoprogression and Pseudoresponse: Challenges in Brain Tumor Imaging. Curr Neurol Neurosci Rep. 2009;9(3):241-6. <a href="https://doi.org/10.1007/s11910-009-0035-4">doi:10.1007/s11910-009-0035-4</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/19348713">Pubmed</a>
Sections changed:
- Approach
Systems changed:
- Central Nervous System
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