Unicentric Castleman disease

Last revised by Rohit Sharma on 2 Jul 2023

Unicentric Castleman disease (UCD) is considered the more common form of Castleman disease and involves one or more enlarged lymph nodes in a single region of the body that demonstrates histopathologic features that have features of Castleman disease. A subset of patients can have systemic symptoms.

Location 

Unicentric Castleman disease is most commonly found in the mediastinum, where it appears as an avidly enhancing mass that displaces surrounding structures 1.

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