Visceral pleural invasion
Updates to Article Attributes
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Visceral pleural invasion is a feature that can be seen in lung cancers. It is defined as tumour extension beyond the elastic layer of the visceral pleura. It is considered an aggressive sign and one of the most important adverse prognostic factors in non-small cell lung cancers 1.
Pathology
Grading
There are three described levels of invasion (based on histology):
- PL0: represents tumour invading either the subpleural lung parenchyma or superficially the pleural connective tissue beneath the elastic layer
- PL1: refers to a tumour that invades beyond the elastic layer without being exposed on the pleural surface
- PL2: refers to a tumour that is exposed on the pleural surface, but it does not involve adjacent anatomic structures
Radiographic features
CT
The presence of type 2 pleural tags has been shown to have a moderate association with visceral pleural invasion 7.
Prognosis
According to one study, there was ~20% (range 10-30%) worse 5-year survival in tumours with visceral pleural invasion compared to those without visceral pleural invasion.
-<p><strong>Visceral pleural invasion</strong> is a feature that can be seen in <a title="Primary lung cancers" href="/articles/lung-cancer-3">lung cancers</a>. It is defined as tumour extension beyond the elastic layer of the visceral pleura. It is considered an aggressive sign and one of the most important adverse prognostic factors in <a href="/articles/non-small-cell-lung-cancer">non-small cell lung cancers</a> <sup>1</sup>.</p><h4>Pathology</h4><h5>Grading</h5><p>There are three described levels of invasion:</p><ul>- +<p><strong>Visceral pleural invasion</strong> is a feature that can be seen in <a href="/articles/lung-cancer-3">lung cancers</a>. It is defined as tumour extension beyond the elastic layer of the visceral pleura. It is considered an aggressive sign and one of the most important adverse prognostic factors in <a href="/articles/non-small-cell-lung-cancer">non-small cell lung cancers</a> <sup>1</sup>.</p><h4>Pathology</h4><h5>Grading</h5><p>There are three described levels of invasion (based on histology):</p><ul>
-</ul><h4>Prognosis</h4><p>According to one study, there was ~20% (range 10-30%) worse 5-year survival in tumours with visceral pleural invasion compared to those without visceral pleural invasion.</p>- +</ul><h4>Radiographic features</h4><h5>CT</h5><p>The presence of <a title="type 2 pleural tags" href="/articles/type-2-pleural-tags">type 2 pleural tags</a> has been shown to have a moderate association with visceral pleural invasion<sup> 7</sup>.</p><h4>Prognosis</h4><p>According to one study, there was ~20% (range 10-30%) worse 5-year survival in tumours with visceral pleural invasion compared to those without visceral pleural invasion.</p>
References changed:
- 6 . Imai K, Minamiya Y, Ishiyama K, Hashimoto M, Saito H, Motoyama S, Sato Y, Ogawa J. Use of CT to evaluate pleural invasion in non-small cell lung cancer: measurement of the ratio of the interface between tumor and neighboring structures to maximum tumor diameter. Radiology. 267 (2): 619-26. <a href="https://doi.org/10.1148/radiol.12120864">doi:10.1148/radiol.12120864</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/23329658">Pubmed</a> <span class="ref_v4"></span>
- 7. Hsu JS, Han IT, Tsai TH, Lin SF, Jaw TS, Liu GC, Chou SH, Chong IW, Chen CY. Pleural Tags on CT Scans to Predict Visceral Pleural Invasion of Non-Small Cell Lung Cancer That Does Not Abut the Pleura. Radiology. 279 (2): 590-6. <a href="https://doi.org/10.1148/radiol.2015151120">doi:10.1148/radiol.2015151120</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/26653684">Pubmed</a> <span class="ref_v4"></span>
- 7. Hsu JS, Han IT, Tsai TH, Lin SF, Jaw TS, Liu GC, Chou SH, Chong IW, Chen CY. Pleural Tags on CT Scans to Predict Visceral Pleural Invasion of Non-Small Cell Lung Cancer That Does Not Abut the Pleura. Radiology. 279 (2): 590-6. <a href="https://doi.org/10.1148/radiol.2015151120">doi:10.1148/radiol.2015151120</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/26653684">Pubmed</a> <span class="ref_v4"></span>
- 6. Hsu JS, Han IT, Tsai TH, Lin SF, Jaw TS, Liu GC, Chou SH, Chong IW, Chen CY. Pleural Tags on CT Scans to Predict Visceral Pleural Invasion of Non-Small Cell Lung Cancer That Does Not Abut the Pleura. Radiology. 279 (2): 590-6. <a href="https://doi.org/10.1148/radiol.2015151120">doi:10.1148/radiol.2015151120</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/26653684">Pubmed</a> <span class="ref_v4"></span>
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