Vitamin B6

Last revised by Daniel J Bell on 2 Aug 2021

Citation, DOI, disclosures and article data

Citation:

Hacking C, Bell D, Weerakkody Y, Vitamin B6. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-50107

DOI:

https://doi.org/10.53347/rID-50107

Permalink:

https://radiopaedia.org/articles/50107

rID:

50107

Article created:

19 Dec 2016, Craig Hacking ◉ ◈

Disclosures:

At the time the article was created Craig Hacking had no recorded disclosures.

View Craig Hacking's current disclosures

Last revised:

2 Aug 2021, Daniel J Bell ◉

Disclosures:

At the time the article was last revised Daniel J Bell had no recorded disclosures.

View Daniel J Bell's current disclosures

Revisions:

11 times, by 3 contributors - see full revision history and disclosures

Sections:

Pathology

Synonyms:

Pyridoxine
Pyridoxal
Pyridoxamine
Hyperpyridoxinemia
Hyperpyridoxinaemia

Vitamin B₆ is a group of water-soluble vitamins, part of the vitamin B complex, and that are derivatives of pyridine, the main vitamers are known as pyridoxine, pyridoxal and pyridoxamine. All three form part of the coenzyme pyridoxal 5'-phosphate (PLP) which is involved in many cellular reactions including the synthesis of several amino acids and the metabolism of glucose and lipids. Vitamin B₆ is one of the hematinics.

The antitubercular drug isoniazid is an inactive derivative of pyridoxal phosphate, hence vitamin B₆ needs to be co-administered to patients on isoniazid.

Related pathology

vitamin B₆deficiency (hypovitaminosis B₆) is rare, seen in alcoholics, women on the oral contraceptive pill (OCP) and neonates fed on B₆-deficient formula
vitamin B₆ excess (hypervitaminosis B₆) may produce neurological symptoms