Presentation
This patient presented with intellectual disability, speech, and language delay, and hyperactivity.
Patient Data
The MRI sagittal T2-weighted images of the brain demonstrate diffuse thickening of the corpus callosum without any focal lesions or abnormal signal intensity. Normal signal intensity is also seen on FLAIR sequence. No white matter lesions are observed. No abnormal cortical signal intensity is identified.
Persistent cavum septum pellucidum et vergae is noted. Mucosal thickening is observed in the maxillary antra and right sphenoid sinus.
Measurement of the thickness of the corpus callosum, at the level of the genu (1.60 cm), body (7.39 mm), isthmus (6.28 mm), and splenium (1.26 cm).
Case Discussion
A thick corpus callosum without a focal lesion can be observed in some normal individuals. However, it may also indicate underlying abnormalities in the connecting tracts of the brain, as seen in neurodevelopmental disorders such as autism spectrum disorder or schizophrenia. This seems to be the case for this teenager, who exhibits various symptoms suggestive of abnormal brain function, including abnormal behavior, mental and language delays, and hyperactivity.
Acknowledgment: Nusaibah Ghaleb Yousef Alnahari
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