Glioblastoma NOS
Diagnosis almost certain
Disclosures
- updated 8 Sep 2022:
Nothing to disclose
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Glioblastoma NOS(IDH-Wild)
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The patient went on to have a biopsy.
Histology
Sections revealed brain tissue infiltrated by malignant astrocytic tumour compromised of malignant astrocytes with pleomorphic nuclei, increased nuclear-cytoplasmic ratio, prominent nucleoli and frequent mitosis. Vascular proliferation was detected in the form of small blood vessel proliferation and endothelial proliferation with occasional glomeruloid morphology. Focal necrosis was observed.
Final diagnosis
WHO CNS grade 4 astrocytic tumour.
Awaiting IDH status to distinguish between diffuse astrocytoma and glioblastoma.Immunostain:
P53: negative staining
IDH1;Negative staining
GFAP:Diffuse positive staining
K167:Proliferation index 8%
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