Glioblastoma with primitive neuronal components
Updates to Case Attributes
The patient presented to EDthe Emergency departmental at a regional hospital. On initial CT, the differential diagnoses suggested included glioma/astrocytoma and gangliogloma. MRI was not organised initially due to concerns about pacemaker compatibility. The patient was transferred to a tertiary centre and underwent resection.
Biopsy demonstrated glioblastoma, IDH-wildtype, with primitive neuronal component, MGMT promoter methlyated (average CpG site methylation rate 21%). The tumour was negative for 1p/19q co-deletion, EGFR amplification, IDH1/IDH2, BRAF, H3F3A mutations.
GB-PNC are a rare subtype of glioblastoma (~0.5%), with components arising from the primitive neuroectoderm. They are associated with a more aggressive course, and more prone to CSF dissemination.
-<p>The patient presented to ED at a regional hospital. On initial CT, the differential diagnoses suggested included glioma/astrocytoma and gangliogloma. MRI was not organised initially due to concerns about pacemaker compatibility. The patient was transferred to a tertiary centre and underwent resection.</p><p>Biopsy demonstrated glioblastoma, IDH-wildtype, with primitive neuronal component, MGMT promoter methlyated (average CpG site methylation rate 21%). The tumour was negative for 1p/19q co-deletion, EGFR amplification, IDH1/IDH2, BRAF, H3F3A mutations.</p><p>GB-PNC are a rare subtype of glioblastoma (~0.5%), with components arising from the primitive neuroectoderm. They are associated with a more aggressive course, and more prone to CSF dissemination.</p>- +<p>The patient presented to the Emergency departmental at a regional hospital. On initial CT, the differential diagnoses suggested included glioma/astrocytoma and gangliogloma. MRI was not organised initially due to concerns about pacemaker compatibility. The patient was transferred to a tertiary centre and underwent resection.</p><p>Biopsy demonstrated glioblastoma, IDH-wildtype, with primitive neuronal component, MGMT promoter methlyated (average CpG site methylation rate 21%). The tumour was negative for 1p/19q co-deletion, EGFR amplification, IDH1/IDH2, BRAF, H3F3A mutations.</p><p>GB-PNC are a rare subtype of glioblastoma (~0.5%), with components arising from the primitive neuroectoderm. They are associated with a more aggressive course, and more prone to CSF dissemination.</p>
Updates to Study Attributes
CT brain pre- and post-contrast demonstrates a largeLarge cystic mass in the left temporal lobe with peripheral enhancement, with minor anterolateral nodularity, but no large solid component. Moderate vasogenic oedema and mass effect, with 7mm of midline shift, ipsilateral lateral ventricle narrowing with contralateral dilatation, and early uncal herniation. No cerebellar tonsillar herniation.
No other intracranial lesions. No
evidence of dural or leptomeningeal enhancement.
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