Primary mediastinal giant cell tumor

A mass is present in the left chest within the interpleural space, measuring approximately 100 x 130 x 122 mm (width x height x length). It shows heterogeneous density, involves and enhancement suggesting areas of necrosis. The mass displaces the diaphragm, and is contiguous with the costal cartilages, and ribs, with. There is a clear boundary withseparation from the middlevisceral mediastinum. No appearances of osteolytic lesions are observed, The mass contains areas of low density suggestive of necrosis. A feeding artery is identifiedFeeding arteries arise from both the celiaccoeliac trunk artery and the internal mammary artery.

There is bilateralLeft pleural effusion.

I. Gross description:

The spicemens appeared brown, grey and soft, measuring from 1.5 cm to 1.8 cm.

II. Microscopic description:

On a slide prepared from the received specimens and stained with Hematoxylinhaematoxylin and Eosin (HE)eosin: Biopsies taken from tumor tissue consist of osteoclast-like multinucleated giant cells located on a background of mononuclear cells. The nuclei of giant cells and mononuclear cells are round or oval, small and even in size, some nuclei are notched, the pigment is smooth, and mitotic nuclei are rare. The interstitium is infiltrated with scattered lymphocytes

III. Conclusion:

Giant cell tumor.

In this case, it was unclear on the CT scan whether the mass was arising from the rib, pleura, or soft tissue. Our initial diagnosis suggested a likelywas solitary fibrous tumour or mesothelioma. Subsequently, however a CT-guided core biopsy of the mass was performed, revealingrevealed a giant cell tumour with benign features.

Primary mediastinal giant cell tumour is a rare tumour that demonstratescan demonstrate a spectrum of benign to malignant characteristics.