Items tagged “rg_40_1_edit”

5 results found
Article

Dementia with Lewy bodies

Dementia with Lewy bodies (DLB), also known as Lewy body disease, is a neurodegenerative disease (a synucleinopathy to be specific) related to Parkinson disease. Epidemiology Dementia with Lewy bodies presents in older patients (onset typically in 50-70 years of age), and is sporadic 1,2,7.  ...
Article

Synucleinopathy

Synucleinopathies are a subgroup of neurodegenerative diseases, characterized by impairment of alpha-synuclein metabolism, resulting in abnormal intracellular deposits. They can further be divided into those with and those without the formation of Lewy bodies, although it should be noted that so...
Article

Tauopathy

Tauopathies are a heterogeneous group of neurodegenerative diseases characterized by abnormal metabolism of misfolded τ (tau) proteins leading to intracellular accumulation and formation of neurofibrillary tangles (NFT). These neurofibrillary tangles are deposited in the cytosol of neurons and g...
Article

Parkinson disease

Parkinson disease (PD), also known as idiopathic Parkinson disease (iPD), is a neurodegenerative disease and movement disorder characterized by resting tremor, rigidity and hypokinesia due to progressive degeneration of dopaminergic neurons in the substantia nigra.  Epidemiology Parkinson dise...
Article

Alzheimer disease

Alzheimer disease is a common neurodegenerative disease, responsible for 60-80% of all dementias, and imposing a significant burden on developed nations. It is associated with an accumulation and deposition of cerebral amyloid-β (Aβ) and is the most common cerebral amyloid deposition disease.  ...

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