Melphalan associated pulmonary toxicity
Last revised by David Luong on 12 Jul 2021
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Luong D, Melphalan associated pulmonary toxicity. Reference article, Radiopaedia.org (Accessed on 10 Jun 2024) https://doi.org/10.53347/rID-76607
Permalink:
rID:
76607
Article created:
24 Apr 2020,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
12 Jul 2021,
David Luong ◉
Disclosures:
At the time the article was last revised David Luong had no recorded disclosures.
View David Luong's current disclosures
Revisions:
3 times, by
2 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- Melphalan related pulmonary toxicity
- Melphalan associated lung toxicity
- Melphalan related lung toxicity
- Melphalan lung toxicity
Melphalan-associated pulmonary toxicity is a rare form of drug induced lung disease. It is an alkylating agent and toxicity has usually been described with high dose. Typically a diffuse interstitial pneumonitis has been described.
References
- 1. Akasheh MS, Freytes CO, Vesole DH. Melphalan-associated pulmonary toxicity following high-dose therapy with autologous hematopoietic stem cell transplantation. (2000) Bone marrow transplantation. 26 (10): 1107-9. doi:10.1038/sj.bmt.1702664 - Pubmed
- 2. Westerfield BT, Michalski JP, McCombs C, Light RW. Reversible melphalan-induced lung damage. (1980) The American journal of medicine. 68 (5): 767-71. doi:10.1016/0002-9343(80)90269-7 - Pubmed
- 3. https://journal.chestnet.org/article/S0012-3692(16)49645-5/fulltext - to be linked
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