Paradoxical reaction in tuberculosis

Last revised by David Luong on 12 Jul 2021

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Luong D, Bell D, et al. Paradoxical reaction in tuberculosis. Reference article, Radiopaedia.org (Accessed on 10 Jun 2024) https://doi.org/10.53347/rID-83660

DOI:

https://doi.org/10.53347/rID-83660

Permalink:

https://radiopaedia.org/articles/83660

rID:

83660

Article created:

31 Oct 2020, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

12 Jul 2021, David Luong ◉

Disclosures:

At the time the article was last revised David Luong had no recorded disclosures.

View David Luong's current disclosures

Revisions:

4 times, by 4 contributors - see full revision history and disclosures

Systems:

Chest

Synonyms:

Paradoxical reaction in TB
Paradoxical upgradation response in non-HIV tuberculosis

A paradoxical reaction in tuberculosis refers to a clinical or radiological worsening of pre-existing tuberculous lesions or the development of new lesions, in patients receiving anti-tuberculous medication who may have initially improved on treatment.

Pathology

The exact mechanism is not well known although an abnormal immune response or reconstitution of the immune system has been suggested. Therefore is more commonly (but not always) seen in HIV co-infected individuals.