Articles

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1,116 results found
Article

Inverted papilloma

Inverted papillomas are a type of Schneiderian papilloma, representing an uncommon non-cancerous sinonasal tumor that mostly affects middle-aged men. They may rarely undergo malignant transformation, most commonly into squamous cell carcinoma. On imaging, they classically demonstrate a convolute...
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Meningeal hemangiopericytoma (historical)

Hemangiopericytomas of the meninges are rare tumors of the meninges, now considered to be an aggressive form of solitary fibrous tumors of the dura. They often present as large and locally aggressive dural masses, frequently extending through the skull vault. They are difficult to distinguish on...
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Colorectal cancer

Colorectal cancer (CRC) is the most common cancer of the gastrointestinal tract and is one of the most frequently diagnosed malignancies in adults. CT is the mainstay for colon cancer locoregional staging and MRI is the mainstay for rectal cancer locoregional staging. This article focuses on co...
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Superficial CD34-positive fibroblastic tumor

Superficial CD34-positive fibroblastic tumors (SCPFT) or PRDM10-rearranged soft tissue tumors are rare low-grade mesenchymal neoplasms of the dermis and subcutis 1-3 that have been just added to the WHO classification of soft tissue tumors in 2020 2,3. Epidemiology Superficial CD34-positive fi...
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Sinonasal carcinoma

Sinonasal carcinomas are a broad group of sinonasal malignant tumors that are of epithelial cell origin/lineage. Pathology Sinonasal carcinomas can be classified into various histological and etiological subgroups: sinonasal squamous cell carcinoma: considered the most common histological sub...
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T-prolymphocytic leukemia

T-prolymphocytic leukemia (T-PLL) is a rare and unusual hematological malignancy. Terminology In the WHO classification, this is referred to as T-prolymphocytic leukemia rather than T-cell prolymphocytic leukemia. Epidemiology It represents around 2% of all mature lymphocytic leukaemias in a...
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Intramuscular hemangiomas

Intramuscular hemangiomas, also known as intramuscular angiomas, intramuscular capillary-type hemangiomas, and intramuscular fast-flow vascular anomalies 5, are vascular lesions consisting of benign vascular channels within skeletal muscle. Terminology In much of the scientific literature, the...
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High-grade astrocytoma with piloid features

High-grade astrocytoma with piloid features (HGAP) is a rare tumor most commonly encountered in the posterior fossa of adults, especially those with neurofibromatosis type 1. It appears heterogeneous and has a relatively poor prognosis.  Epidemiology Due to the small number of patients reporte...
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Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS US)

The Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS US) forms the ultrasound component of the Ovarian-Adnexal Reporting and Data System (O-RADS). This system aims to ensure that there are uniform unambiguous sonographic evaluations of ovarian or other adnexal lesions, accurately ass...
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EWSR1-SMAD3-positive fibroblastic tumor

EWSR1-SMAD3-positive fibroblastic tumors are benign mesenchymal neoplasms with different morphologies and a provisional name 1-4 that was and added to the WHO classification of soft tissue tumors in 2020 2,3. Epidemiology EWSR1-SMAD3-positive fibroblastic tumors are sporadic soft tissue neopla...
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Mucinous adenocarcinoma of the prostate

Mucinous adenocarcinomas of the prostate or colloid adenocarcinomas of the prostate are a variant of acinar adenocarcinoma and characterized by mucinous features. Epidemiology Mucinous adenocarcinomas of the prostate are rare and account for less than 0.5% of prostate cancers 1-4. Diagnosis ...
Article

Medulloblastoma

Medulloblastomas are the most common malignant brain tumors of childhood, most often presenting as midline masses in the roof of the 4th ventricle (at the superior medullary velum) with associated mass-effect and hydrocephalus. Treatment typically consists of surgical resection, radiation therap...
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WAGR syndrome

WAGR syndrome or complex stands for: Wilms tumors (greatly increased risk) aniridia genitourinary anomalies intellectual disability Pathology Genetics Occurs from a mutation related to chromosome 11p13 3 which is in close proximity to the WT1 gene.
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Aflatoxins

Aflatoxins are naturally-occurring mycotoxins that are produced by Aspergillus species, especially Aspergillus flavus. They are acutely toxic and carcinogenic. Acute exposure High-level aflatoxin exposure can result in acute aflatoxicosis with acute hepatic necrosis, leading to cirrhosis, and ...
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Rubinstein-Taybi syndrome

Rubinstein-Taybi syndrome (RTS) is a very rare genetic multi-system disorder primarily characterized by intellectual disability, broad and often angulated thumbs and halluces, and distinctive facial features. Epidemiology The estimated incidence is 1 in 100,000-125,000 live births 5. Clinical...
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Diffuse hemispheric glioma H3 G34 mutant

Diffuse hemispheric gliomas, H3 G34 mutant are rare and high grade infiltrating tumors typically presenting in adolescents and young adults. Terminology Diffuse hemispheric gliomas H3 G34 mutant have been included in the 5th Edition (2021) of the WHO brain tumor classification 1 among the "ped...
Article

Myxoid pleomorphic liposarcoma

Myxoid pleomorphic liposarcomas are extremely rare aggressive malignant neoplasms arising from adipocytic tissues characterized by a mixture of pleomorphic and myxoid features and the absence of genetic fusions and amplifications seen in well-differentiated liposarcoma and other lines of differe...
Article

Rectal cancer response assessment

Assessment of rectal cancer response to therapy, which may be chemotherapy, radiotherapy, or a combination, relies on the synthesis of clinical, endoscopic and radiologic evaluation.  The purpose of neoadjuvant therapy is to downstage the tumor, to facilitate surgical resection, and reduce loca...
Article

Choledochal cyst

Choledochal cysts represent congenital cystic dilatations of the biliary tree. Diagnosis relies on excluding other conditions as a cause of biliary duct dilatation, e.g. tumor, gallstone, inflammation. Epidemiology Choledochal cysts are rare, with an incidence of 1:100,000-150,000. Although th...
Article

Gynecologic Imaging-Reporting and Data System (GI-RADS)

The Gynecologic Imaging-Reporting and Data System (GI-RADS) is a reporting system that was created for reporting the findings in adnexal masses based on transvaginal ultrasonography. Classification Findings are classified into five categories 1: GI-RADS 1 normal ovaries identified and no adn...

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