Articles

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337 results found
Article

Sézary syndrome

Sézary syndrome (SS) is a type of primary cutaneous T-cell lymphoma.  Clinical presentation It is clinically characterized by an extensive erythematous rash covering most of the body as well as the presence of malignant lymphocytes in the blood. History and etymology It is named after Albert...
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Pancreatic lymphoma

Pancreatic lymphoma is most commonly a B-cell subtype of non-Hodgkin lymphoma Epidemiology Pancreatic lymphoma is typically seen in middle-aged patients with a mean age of around 55 years old and is more common in immunocompromised patients. Clinical presentation Symptoms are often non-speci...
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Primary ovarian lymphoma

Primary ovarian lymphoma (POL) refers to the involvement of the ovary with lymphoma but without the involvement of any other site. It is an extremely rare yet well-recognized condition. Epidemiology Primary ovarian lymphoma accounts for ~1.5% of ovarian tumors 5. Pathology The rarity of this...
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Lugano staging classification

The Lugano staging classification is the lymphoma staging system that is most commonly used in clinical practice currently. The categories for initial staging are defined in this article. See separate articles for the Lugano criteria for response assessment by PET-CT or by CT alone, as well as g...
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Myelodysplastic syndrome

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological stem cell disorders characterized by dysplasia and ineffective hematopoiesis. It carries a risk of transformation to acute leukemia. Epidemiology Its overall incidence is thought to be around 3.3 per 100,000. The...
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Apheresis

Apheresis is an extracorporeal procedure in which the main components of blood (red blood cells, plasma, and plasma proteins) are separated and removed from the body. It is used as therapeutic measure for certain conditions. Radiological implications It is one of the indications of placement o...
Article

T-prolymphocytic leukemia

T-prolymphocytic leukemia (T-PLL) is a rare and unusual hematological malignancy. Terminology In the WHO classification, this is referred to as T-prolymphocytic leukemia rather than T-cell prolymphocytic leukemia. Epidemiology It represents around 2% of all mature lymphocytic leukaemias in a...
Article

Anion gap metabolic acidosis causes (mnemonic)

A mnemonic to remember the commonest causes of anion gap metabolic acidosis is: GOLDMARK Mnemonic G: glycols (ethylene glycol and propylene glycol) O: oxoproline L: L-lactate D: D-lactate M: methanol A: aspirin R: renal failure K: ketoacidosis
Article

Primary hepatic lymphoma

Primary hepatic lymphoma (PHL) is very rare, with approximately 100 described cases. If it is being considered as a diagnosis, distant lymphadenopathy, splenomegaly, bone marrow disease, and leukemia should not be present for at least 6 months after the liver tumor has been detected (see: second...
Article

Transient abnormal myelopoiesis

Transient abnormal myelopoiesis (TAM) is a phenomenon that can happen in the fetuses or neonates with trisomy 21. The condition can mimic leukemia. Epidemiology The estimated incidence is at ~10% of newborns with trisomy 21 3. Radiographic features Antenatal ultrasound In the context of kno...
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Reticuloendothelial system

The reticuloendothelial system (RES) comprises a number of tissues: spleen bone marrow liver Kupffer cells
Article

Large bowel lymphoma

Large bowel (colorectal) lymphoma is a very rare tumor, accounting for <0.5% of primary colorectal malignancies, ~1.5% of all lymphomas, and ~15% of gastrointestinal lymphomas. Large bowel lymphoma differs from gastric and small bowel lymphoma in clinical presentation, management, and prognosis....
Article

Lugano classification (response to treatment on CT)

The Lugano classification is a lymphoma staging system resulting from recommended changes in 2011 to the Ann Arbor staging with Cotswolds modifications. This article outlines the classification's response to treatment based on CT.  Also included in the classification are staging and response to...
Article

Thrombocytopenia causes (mnemonic)

A mnemonic to remember the commonest causes of thrombocytopenia is: PLATELETS Mnemonic P: platelet disorders (DIC, TTP, ITP) L: leukemia  A: anemia T: trauma E: enlarged spleen L: liver disease E: ethanol T: toxicity (heparin, aspirin, chemotherapy, benzene) S: sepsis
Article

Felty syndrome components (mnemonic)

Felty syndrome is a rare condition that involves rheumatoid arthritis, decreased white blood cell count and spleen enlargement. A mnemonic to remember the basic components of Felty syndrome is: SANTA Mnemonic S: splenomegaly  A: anemia N: neutropenia T: thrombocytopenia A: arthritis (rhe...
Article

Hemochromatosis

Hemochromatosis is an iron overload disorder characterized by a progressive increase in total body iron stores and deposition of iron in some non-reticuloendothelial system (RES) body organs which results in some instances of organ dysfunction. This article focuses on the general principles of ...
Article

Lymphoma of the spinal cord

Lymphoma of the spinal cord is an uncommon manifestation of lymphoma. Although lymphoma more commonly involves the vertebral body (vertebral body tumors) or epidural compartment, intramedullary lymphoma may rarely occur.   Apparent intramedullary spinal cord lymphoma may often, in fact, represe...
Article

Pulmonary artery stump thrombosis

Pulmonary artery stump thrombosis describes thrombus formation occurring at the site of the pulmonary arterial stump, a complication following lobectomy or pneumonectomy. It is usually discovered as an incidental finding on routine follow-up chest CT scans. Epidemiology The prevalence of pulmo...
Article

Tumors associated with increased erythropoetin

Tumors associated with increased erythropoetin are varied and numerous. Patients will be polycythemic due to erythropoetin secretion. Tumors in this group include: renal cell carcinoma (RCC) 2 hepatocellular carcinoma (HCC) hemangioblastoma
Article

Anemia

Anemia is the presence of reduced hemoglobin in the blood. Formally, the World Health Organizatiοn (WHO) defines anemia by the hemoglobin concentration in the blood according to age and sex 1: adult men: <130 g/L adult women: <120 g/L Values for pregnant women and children are different. Cli...

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