Articles

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1,114 results found
Article

Testicular seminoma

Testicular seminomas are a type of germ cell tumor and the most common testicular tumor, accounting for ~45% of all primary testicular tumors. This article concerns only testicular seminomas; however, seminomas can arise outside of the testis, most often within the anterior mediastinum (see arti...
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Clear cell renal cell carcinoma

Clear cell renal cell carcinoma is the most common type of renal cell carcinoma.  Epidemiology The average age of onset of sporadic clear cell renal carcinoma is 61 years. In cases associated with von Hippel-Lindau disease, the average age of onset is 37 years 1. Clinical presentation Patien...
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Leukemia

Leukemia is a hematological neoplasm characterized by the overproduction of immature (blasts) or abnormally differentiated cells of the hematopoietic system in the bone marrow that often, but not always, extends into the peripheral blood.  This article aims to provide an overview of leukemia as...
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Zurich pituitary score

The Zurich pituitary score is a quantitative classification of pituitary adenomas based on coronal T1-weighted magnetic resonance imaging with contrast, although the score can also be obtained with computed tomography. The Zurich pituitary score is based on the ratio between the horizontal tumo...
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Pulmonary hamartoma

Pulmonary hamartomas (alternative plural: hamartomata) are benign neoplasms composed of cartilage, connective tissue, muscle, fat, and bone. It is one of the most common benign lung tumors, accounting for ~8% of all lung neoplasms and 6% of solitary pulmonary nodules. Terminology Pulmonary cho...
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Ewing sarcoma

Ewing sarcomas are the second most common malignant primary bone tumors of childhood after osteosarcoma, typically arising from the medullary cavity with the invasion of the Haversian system. Ewing sarcomas usually present as moth-eaten, destructive, and permeative lucent lesions in the shaft of...
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Cystic adrenal neoplasm

Cystic adrenal neoplasms are uncommon and only account for a minority of cystic adrenal lesions 3. There may be several histological types: adrenal adenoma 1 adrenal cortical carcinoma 1,2 adrenal epithelioid angiosarcoma 2 pheochromocytoma 1 teratoma (pediatric population) 4 Differential ...
Article

Osteoid osteoma

Osteoid osteomas are benign bone-forming tumors that typically occur in children (particularly adolescents). They have a characteristic lucent nidus <1.5 or 2 cm and surrounding osteosclerotic reaction, which classically causes night pain that is relieved by the use of NSAIDs. Epidemiology Ost...
Article

Pancreatic acinar cell carcinoma

Pancreatic acinar cell carcinomas are rare exocrine neoplasms that comprise ~1% of all pancreatic tumors. This tumor shows more aggressive behavior than the far more common adenocarcinoma 1,3,4. Epidemiology This tumor is most common in pediatric (8-15 years) and adult (60 years) populations. ...
Article

Asbestosis

Asbestosis is an occupational fibrotic lung disease associated with high levels of asbestos fiber inhalation. Fibrosis is lower lobe predominant and can progress. Even without progression the risk of lung cancer is increased. The presence of pleural plaques is variable 10. Epidemiology Asbest...
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Adenocarcinoma of the lung

Adenocarcinoma of the lung is the most common histologic type of lung cancer. Grouped under the non-small cell carcinomas of the lung, it is a malignant tumor with glandular differentiation or mucin production expressing in different patterns and degrees of differentiation.  This article brings...
Article

Paraneoplastic cerebellar degeneration

Paraneoplastic cerebellar degeneration is a type of paraneoplastic syndrome, and manifestation of autoimmune encephalitis, characterized by the progressive onset of cerebellar dysfunction not explained by tumoral invasion, metastasis, or treatment side effects. Clinical presentation Cerebellar...
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Milan criteria in liver transplantation

The Milan criteria are used to assess suitability in patients for liver transplantation with cirrhosis and hepatocellular carcinoma (HCC) with comparable outcomes when compared to patients with liver cirrhosis but without HCC 3. Usage The Milan criteria are widely accepted and used, however, t...
Article

Three-territory sign (brain)

The three-territory sign is a radiological sign described in ischemic stroke and is highly specific to hypercoagulability due to malignancy (Trousseau syndrome) being the etiology. However, this sign is not pathognomonic, and may be seen with cardioembolic stroke (e.g. due to atrial fibrillation...
Article

Esophageal and esophagogastric junction squamous cell carcinoma (staging)

Esophageal and esophagogastric junction squamous cell carcinoma staging refers to TNM staging of squamous cell carcinoma originating in the esophagus or esophagogastric junction (including tumors whose center is within the proximal 2 cm of the gastric cardia). Related histologies included in th...
Article

Extramural vascular invasion (EMVI)

Extramural vascular invasion (EMVI) is the direct invasion of a blood vessel (usually a vein) by a tumor. In colorectal cancer, this can occur on a macroscopic level and be detected on staging MRI (mrEMVI) and/or CT 1-6. It is a significant prognostic factor, being a predictor of hematogenous sp...
Article

Spinal astrocytoma

Spinal astrocytomas are the second most common spinal cord tumor, representing 40% of intramedullary tumors 3. They account for 60% of pediatric intramedullary tumors, making them the most common spinal cord tumor in children 6. This article specifically relates to spinal astrocytomas. For a di...
Article

Synovial sarcoma

Synovial sarcomas are relatively common intermediate-to-high grade malignant soft tissue tumors, often with an initial indolent course, affecting young patients and most commonly involving the soft tissue surrounding the knees. Epidemiology Synovial sarcomas typically present in adolescents an...
Article

DICER1 syndrome

DICER1 syndrome is a rare autosomal dominant disorder predisposing individuals to the development of multiple tumor types. Epidemiology DICER1 syndrome most commonly manifests in children, adolescents and young adults 8. Clinical presentation The clinical presentation will depend on the pa...
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Undifferentiated embryonal sarcoma of the liver

Undifferentiated embryonal sarcomas of the liver are rare, aggressive, and malignant liver tumors encountered in the pediatric population.  Epidemiology Approximately 90% of cases occur in patients under 15 years of age, most commonly between 6 and 10 years of age, but some cases have been rep...

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