Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Baba Y, Elfeky M, Left atrial appendage thrombus. Reference article, Radiopaedia.org (Accessed on 11 May 2024) https://doi.org/10.53347/rID-163481
Left atrial appendage thrombus is a site of intra-cardiac thrombus and refers to the presence of thrombus within the left atrial appendage.
The left atrial appendage is considered the main location of thrombus formation, predominantly in patients with non-valvular atrial fibrillation.
Radiographic features
Cardiac CT
Maybe reasonably specific but not as much sensitive 7.
Thrombus detection by cardiac CT relies on filling defects within the left atrial appendage. However, low blood flow velocity may also present as filling defects, and differentiation between thrombi from low blood flow/stasis during early imaging method may be difficult due to the interval between contrast arrival and left atrial appendage image capture being too short. Some authors have suggested a delayed imaging (around 6 minutes) phase to help to differentiate thrombi and low/slow flow 2,5.
Echocardiography
Trans-esophageal echocardiography (TEE/TOE)
Differential diagnosis
On CT in certain situations consider
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1. Yuan N, Rader F, Siegel R. Safe to Go with the Flow? Large Left Atrial Appendage Thrombus Despite Robust Appendage Flow Velocities. European Heart Journal - Cardiovascular Imaging. 2020;22(6):e76. doi:10.1093/ehjci/jeaa290 - Pubmed
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2. Yu S, Zhang H, Li H. Cardiac Computed Tomography Versus Transesophageal Echocardiography for the Detection of Left Atrial Appendage Thrombus: A Systemic Review and Meta‐Analysis. JAHA. 2021;10(23):e022505. doi:10.1161/jaha.121.022505 - Pubmed
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3. Romero J, Cao J, Garcia M, Taub C. Cardiac Imaging for Assessment of Left Atrial Appendage Stasis and Thrombosis. Nat Rev Cardiol. 2014;11(8):470-80. doi:10.1038/nrcardio.2014.77 - Pubmed
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4. García-Fernández M, Torrecilla E, San Román D et al. Left Atrial Appendage Doppler Flow Patterns: Implications on Thrombus Formation. Am Heart J. 1992;124(4):955-61. doi:10.1016/0002-8703(92)90978-5 - Pubmed
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5. Spagnolo P, Giglio M, Di Marco D et al. Diagnosis of Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation: Delayed Contrast-Enhanced Cardiac CT. Eur Radiol. 2021;31(3):1236-44. doi:10.1007/s00330-020-07172-2 - Pubmed
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6. Garcia M. Detection of Left Atrial Appendage Thrombus by Cardiac Computed Tomography. JACC Cardiovasc Imaging. 2009;2(1):77-9. doi:10.1016/j.jcmg.2008.10.003 - Pubmed
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7. Li X, Wang J, Wei Q et al. Diagnostic Value of Delayed Contrast-Enhanced Cardiac Computed Tomography for Detecting Left Atrial Appendage Thrombus in Patients With Atrial Fibrillation. Front Cardiovasc Med. 2022;9:847163. doi:10.3389/fcvm.2022.847163 - Pubmed
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