Which pathology is sometimes associated with chondroblastomas?
Secondary aneurysmal bone cysts (with higher chondroblastoma recurrent rate after curettage treatment).
What are the differential diagnosis's to chondroblastoma?
- clear cell chondrosarcoma: see chondroblastoma vs. clear cell chondrosarcoma - osteomyelitis with abscess, e.g. Brodie abscess - intraosseous ganglion - giant cell tumour: older age group (closed physis)
The tumor consists of polygonal chondroblasts with oval or grooved nuclei with well-defined cell border. Some multinucleated clusters of round histiocytes, spindle-shaped fibroblasts, foam cell transformed macrophages/ siderophages and giant cells were also observed. The mononuclear elements are epitheloid and PAS positive. A cartilage matrix/chondroosteoid formation can be observed in some areas with iron pigment. Immunohistochemically, the tumor cells are positive for S-100 protein.