Metastatic renal cell carcinoma - bones and lungs

Discussion:

Oncologic patient with a history of renal mass on the left treated with radical nephrectomy, the surgical specimen was referred for histopathological study, which confirmed grade IV clear cell renal carcinoma.

Among renal carcinomas, the clear cell subtype is the most common, affecting mainly the population in the age group of 60 to 70 years, with a higher incidence in males. Metastases are usually osteolytic, rapidly evolving, and may culminate in pathologic fractures, with bone metastases being an independent factor of poor prognosis in renal neoplasia, which may directly impact the quality of life of the patient. In the reported scenario, the patient has an indication for surgical intervention (Mirels score = 9 ); however, there is a high chance of developing irreversible sequelae. Due to her clinical situation and comorbidities, conservative treatment was chosen.

Case contributed by: Dr Ana Carolina Freitas, Dr Daniel Medeiros, Dr Leonardo Cordeiro, Dr Aline Freitas and Dr Karen Bueno.

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