Presentation
Cardiac patient on amiodarone for the last 5 years. Otherwise asymptomatic.
Patient Data
Age: 85 years
Gender: Female
From the case:
Amiodarone deposition in the liver
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Diffusely increased hepatic attenuation (average density=90 HU) compared to the normal baseline attenuation values of the spleen.
Case Discussion
Amiodarone, a commonly prescribed antiarrhythmic medication, contains a significant iodine component ( 40% of its molecular weight ). Amiodarone undergoes primary metabolism in the liver, where it is converted to an active metabolite known as desethylamiodarone. Gradual and progressive accumulation of amiodarone and its metabolite desethylamiodarone contributes to increased liver density, primarily attributed to its iodine content.
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