Cerebellar dysplasia

Case contributed by Belal Awwad
Diagnosis almost certain

Presentation

A known case of epilepsy 9 years ago. Currently treated with Depakine-Chrono 500 mg. Still getting attacks of convulsions 1-2 per week, last attack yesterday. Refractory epilepsy.

Patient Data

Age: 25 years
Gender: Female
mri

Abnormal disorganized foliation and sulcal morphology of both cerebellar hemispheres. Prominent cerebellar and vermian size with bilateral small variable sized scattered subcortical foci of CSF signals representing small cerebellar cysts as well as left cerebellar subcortical focal area that follow the grey matter in all pulse sequence in keeping with associated heterotopia.

Right anterior frontal deep sulcal infolding with focal nodular gyral thickening. No associated signal abnormalities, denoting polymicrogyria.

Case Discussion

Cerebellar dysplasia disorders are thought to result from prenatal injury including toxic and hypoxic insults. Search for associated posterior fossa and supra-tentorial anomalies.

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