Glioblastoma NOS

Case contributed by Zhao Feng Liu
Diagnosis certain

Presentation

Headache and right-sided weakness for 1 month.

Patient Data

Age: 55 years
Gender: Female

Initial

mri

Frontoparietal solitary ring-enhancing lesion demonstrating peripheral diffusion restriction with associated surrounding edema and a slight midline shift.

Post-operative

mri

The ovoid T1 hyperintense lesion is consistent with sub-acute blood products in the resected tumor cavity with surrounding vasogenic edema. Overlying craniotomy with trace dural thickening.

Case Discussion

The patient was histologically confirmed to have WHO stage IV glioblastoma NOS (formerly known as glioblastoma multiforme or GBM) 1. The initial scan demonstrates the typical appearance of this tumor, presenting as a large necrotic mass with surrounding vasogenic edema, mass effect, and heterogeneous contrast enhancement 2. The patient underwent stereotactic craniotomy and subsequently adjuvant radiotherapy and temozolomide.

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