Presentation
Headache and personality change.
Patient Data
A mass involves the anterior corpus callosum (forceps minor) and spreads into both frontal lobes. It mildly and heterogeneously enhances and is associated with moderate vasogenic edema.
Case Discussion
Typical appearances of a butterfly glioma. The patient went on to have a biopsy.
Histology
Paraffin sections show fragments of a densely hypercellular glial tumor. Tumor cells are a mixture of fibrillary and gemistocytic astrocytes and several markedly pleomorphic multinucleated tumor giant cells are also noted. Scattered mitotic figures are identified. There are foci of necrosis as well as microvascular proliferation with endothelial cell hyperplasia.
Final diagnosis
Glioblastoma (WHO Grade IV).
Note: IDH mutation status is not provided in this case and, according to the WHO classification of CNS tumors (5th edition), this tumor would, therefore, be designated as a glioblastoma NOS.
Unable to process the form. Check for errors and try again.