Hot cross bun sign

Case contributed by Ali Hekmatnia
Diagnosis almost certain

Presentation

Parkinsonism and ataxia

Patient Data

Age: 35 years
Gender: Female
mri

Typical hot cross bun sign is seen in the pons on T2/FLAIR axial images, associated with brain stem and cerebellar hemisphere atrophy.

Case Discussion

Hot cross bun sign is seen in the pons in a Multiple system atrophy (MSA) patient, the sign has also seen with other neurodegenerative diseases such as spinocerebellar atrophy and parkinsonism. In appropriate clinical setting, detection of these changes is useful to confirm the diagnosis of MSA.

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