Presentation
Required intensive care unit admission for acute hypoxic respiratory failure. Evaluate for underlying pathology.
Patient Data
Bilateral multilobar consolidations and ground glass opacities on a background of centrilobular emphysema. Some sparing of the right lower lobe and left lung base.
Case Discussion
This is a case of suspected ibrutinib-induced-pneumonitis.
The patient has a history of diffuse large B cell lymphoma. He was originally on R-MPV (rituximab, methotrexate, procarbazine, vincristine) but his symptoms of confusion and weakness progressed despite several courses. He was started on ibrutinib at an outside institution 1-2 months prior to this presentation. Ibrutinib has been shown to cause pneumonitis.1,2
Co-authors:
Jun Yang
Camille Dumas, DO
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