Lissencephaly

Case contributed by Mostafa Elfeky
Diagnosis probable

Presentation

Seizures

Patient Data

Age: 14 years
Gender: Male

Brain

mri

Diffuse cortical thickening with scanty shallow sulci and shallow Sylvian fissures. This is associated with reduced volume of the white matter of both cerebral hemispheres. No associated band heterotopia. Normal corpus callosum.

Case Discussion

Features that are suggestive of Lissencephaly (type I); pachygyria-agyria complex.  Features presented are:

  • markedly thickened cortex
  • shallow Sylvian fissures
  • smooth cortical surface
  • reduction in the number of gyri (pachygyria)

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