Otogenic brain abscess

Case contributed by Francis Deng
Diagnosis certain

Presentation

Monthlong history of ear infection treated with antibiotics, found down at home. On arrival, Glasgow Coma Scale 11 and right gaze preference.

Patient Data

Age: 35 years
Gender: Female
ct
  • 3.5 cm right temporal lobe mass with extensive vasogenic edema, likely brain abscess
  • Midline shift of 8 mm leftward, right lateral ventricular temporal horn entrapment, and right uncal herniation
  • Right coalescent otomastoiditis with sigmoid plate dehiscence
  • Right ossicular chain destruction, lateral attic wall erosion, scutum blunting, and tegmen tympani dehiscence, likely due to cholesteatoma

Case Discussion

The patient was treated with levetiracetam and hypertonic saline initially. Mental status deteriorated to Glasgow Coma Scale 5, leading to intubation. The left pupil was then noted to be fixed and dilated, concerning for brain herniation, prompting emergency neurosurgical decompressive hemicraniectomy, abscess drainage, and external ventricular drain placement. Two days later, the otology service performed right mastoidectomy, which revealed cholesteatoma in the epitympanum extending to the aditus ad antrum,  as well as mucopurulence in the middle ear and mastoid cavity. Brain abscess, CSF, and ear operative cultures grew Escherichia coli, Parvimonas micra (Peptostreptococcus micros), Peptoniphilus (Peptostreptococcus) asaccharolyticus, and Actinomyces europaeus. Intravenous antibiotics with Gram negative and anaerobic coverage were administered for 6 weeks.

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