Periventricular leukomalacia with germinal matrix hemorrhage

Case contributed by Hisham Hassan Ibrahem
Diagnosis almost certain

Presentation

Pre-term neonate with hypotonia.

Patient Data

Age: Neonate
Gender: Male

Bilateral intraventricular hemorrhage is seen anterior to the caudothalamic groove associated with ventricular dilation with no parenchymal extension, suggesting germinal matrix hemorrhage (grade III).

Bilateral increased periventricular echogenicity with multiple small periventricular cysts in the occipital and frontoparietal regions, suggesting periventricular leukomalacia (grade III).

Follow-up ultrasound after 10 days demonstrates progressive cystic change of the periventricular leukoencephalopathy and intraventricular hemorrhage.

Case Discussion

Cranial ultrasound for a pre-term neonate shows periventricular leukomalacia grade III and germinal matrix hemorrhage grade III.

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