Post partum cardiomyopathy

Case contributed by Karen Machang'a
Diagnosis probable

Presentation

Easy fatigability, cough, and dyspnea on mild exertion one week after childbirth. Heart rate: 96 bpm. History of pre-eclampsia. No prior history of heart failure.

Patient Data

Age: 40 years
Gender: Female

Echocardiography

ultrasound

Left ventricle:

  • dilated cavity: end-diastolic left ventricular diameter: ~6.8 cm with spontaneous echo contrast

  • no thrombus

  • normal left ventricular wall thickness.

  • impaired systolic function LVEF: ~35%, E point-septal separation (EPSS): 17 mm

  • no regional wall motion abnormalities

  • diastolic dysfunction (grade 2): pseudonormal relaxation pattern with elevated left ventricular end-diastolic pressures (LVEDP) average E/e': 16.8

Right ventricle:

  • normal in size with good systolic function

  • TAPSE: 2.5 cm

  • tissue Doppler imaging systolic velocity (TDI S'): 14.4 cm/s

Interventricular septum: intact

Atria:

  • left atrium: dilated, area: 22.8 cm2

  • right atrium: normal in size

Aortic valve:

  • normal tricuspid

  • moderate aortic regurgitation: pressure half time (PHT): 345 ms

  • mild holodiastolic flow reversal with an end-diastolic velocity of <20 cm/s in the descending aorta

Mitral valve:

  • severe mitral regurgitation with pulmonary vein flow reversal

  • regurgitant volume 220 mLs

  • regurgitant fraction: 69%, EROA: 1.22 cm2 (calculated using the stroke volume method, that is the difference between the inflow and outflow stroke volumes of the left ventricle)

Tricuspid valve:

  • mild tricuspid regurgitation

Additional findings:

  • mildly elevated pulmonary pressures (estimated sPAP ~43 mmHg)

  • dilated IVC with >50% inspirational collapse (not shown)

  • small pericardial effusion

Case Discussion

Postpartum cardiomyopathy is an idiopathic cardiomyopathy that presents with heart failure secondary to left ventricular systolic dysfunction toward the end of pregnancy or the first six months after delivery. The etiology remains unclear but some of the risk factors for the development of postpartum cardiomyopathy are multiple gestation, multiparity, older age, gestational hypertension, preeclampsia, or eclampsia. It can also be idiopathic without any risk factor.

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