Pulmonary alveolar proteinosis

Case contributed by Davina Bates
Diagnosis certain

Presentation

Check ICC position.

Patient Data

Age: 30 years
Gender: Male

Day 1

x-ray

Small left pneumothorax with a left apically directed intercostal catheter in situ. (This was iatrogenic in this case)

Bilateral diffuse symmetrical airspace opacities. No pleural effusion. Normal heart size. 

Day 33

ct

Relatively symmetrical bilateral multilobar ground glass opacities and septal thickening - crazy paving. 

Well-defined geographic regions of spared normal lung. 

Pleural spaces are clear.

No mediastinal lymphadenopathy. 

Post whole lung lavage

ct

Markedly reduced ground glass opacities and septal thickening post whole lung lavage. 

 

Case Discussion

Lung Lavage Cytopathology: Large amount of PAS+ proteinaceous fluid. GMS stain negative for fungi and PJP. 

Anti GM-CSF antibody: positive.

Conclusion: pulmonary alveolar proteinosis

 

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