Testicular mixed germ cell tumor

Case contributed by Ammar Ashraf
Diagnosis certain

Presentation

Right testicular pain for a few weeks, getting worse over the last three days. No urinary symptoms.

Patient Data

Age: 25 years
Gender: Male
ultrasound

Large heterogeneous mass measuring approximately 6 x 6 x 10 cm, almost completely replacing the right testis. Color and pulsed Doppler ultrasound examinations show increased vascularity within the mass.

Large right testicular mass being supplied by an artery arising from the anterior aorta at L3 level between the renal and inferior mesenteric arteries (right testicular artery). It shows heterogeneous enhancement along with multiple non-enhancing cystic/necrotic areas. No abdominopelvic lymphadenopathy or distant metastasis are seen.

Photo

Histopathology showed mixed germ cell tumor (teratoma 50%, seminoma 45% and embryonal cell carcinoma 5%). 

Case Discussion

  • Large heterogeneous right testicular mass likely representing a non seminomatous germ cell tumor, later proven to be a mixed germ cell tumor.

  • Laboratory investigations showed elevated tumor markers {AFP= 107 ng/ml (normal: ~8),  quantitative beta-HCG =29.4 IU/L (normal in males: <5) and LDH=334 U/L (normal: 125-220)}. 

  • Staging workup showed no evidence of distant metastasis. The patient underwent an uneventful radical right inguinal orchiectomy.

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