Histopathology:
MICROSCOPIC DESCRIPTION: Sections of the squamous mucosa show infiltration by poorly differentiated carcinoma. The tumour is about 8mm in depth. It forms sheets and nests with areas of necrosis. No glandular structures are noted. The tumour cells have enlarged pleomorphic nuclei, prominent nucleoli and small amounts of cytoplasm. There is no definite evidence of keratinisation. No evidence of lymphovascular or perineural invasion is seen. The tumour cells are p40 and CK5/6 positive, in keeping with squamous cell carcinoma. Some cells are TTF-1 positive. They are p16, PSA and androgen receptor negative.
DIAGNOSIS: Anterior palate: Poorly differentiated squamous cell carcinoma.