Irregular and delayed ossification of multiple epiphyses with associated genu valgus in a patient with three of the siblings have the same anomalies are suggestive of Multiple epiphyseal dysplasias. 

Multiple epiphyseal dysplasia also known as dysplasia epiphyseal multiplex or Fairbank disease) is inherited in an autosomal dominant pattern characterized by flattening and fragmentation of epiphyses.

Additional contributor: ZE. Boudiaf, MD