Malignant degeneration of low grade glioma

Discussion:

Microscopy: diffuse astrocytoma (fibrillary type) degenerated into anaplastic astrocytoma (WHO grade III).

Diffuse astrocytomas are classified as WHO grade II tumors, with a median survival of 6-10 years, yet with an intrinsic tendency towards malignant transformation into anaplastic astrocytoma (WHO grade III) or glioblastoma multiforme (WHO grade IV).

Differential considerations for this case include ischemia, cerebellitis and tumefactive demyelination.

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