Colorectal cancer is the third most common cancer worldwide. The most common site for metastasis is the liver. Colorectal cancer cells may also spread to the lungs, bones, brain and spinal cord. Symptoms of metastasis vary by location. Risk factors include ulcerative colitis, diabetes, obesity, prior abdominopelvic radiation, and inherited colon cancer syndromes (e.g., Lynch syndrome, familial adenomatous polyposis). Treatment commonly includes surgery and chemotherapy.