The histology report showed "moderately differentiated adenocarcinoma arising from a tubular adenoma invading muscularis propria with no lymphovascular, venous or perineural invasion; no tumour deposits or metastatic carcinoma in lymph nodes (0/17), stage (TNM8) -pT2, pN0; R0 On immunohistochemistry, invasive adenocarcinoma cells show positive nuclear staining with all MMR proteins MLH1, PMS2, MMSH2 and MSH6.
The staining is patchy and weak especially with MLH1 and MSH6. Similar staining is noted in adjacent stromal cells in the tumour.
Interpretation: No complete loss of expression of MMR proteins. There is no evidence of mismatch repair deficiency. CDX2 is diffuse and strong positive."