This is a case of Langerhans cell histiocytosis presenting with destructive lesions in the maxilla and mandible. Bone biopsy of the lesion with immunohistochemical staining showed Langerhan cells positive for CD1a and S100. The patient was treated with bone curettage of the lesions and 6 cycles of cytarabine. Subsequent scans demonstrate recurrent facial bone lesions, new lytic lesion in the femur, and pulmonary involvement.

This case was submitted with supervision and input from:

Diego Davila III, M.D. 

Soni C. Chawla, M.D.

Associate Professor
Department of Radiological Sciences
David Geffen School of Medicine at UCLA
Olive View - UCLA Medical Center